Dominic J. Monetta – former deputy director of Defense Research and Engineering (Research and Advanced Technology) at the U.S. Department of Defense from 1991 to 1993, and former director, Office of New Production Reactors, at the United States Department of Energy from 1989 to 1991
Thomas McNamara '62 – former Assistant Secretary of State for Political-Military Affairs and U.S. Ambassador to Colombia
Chang Myon – 2nd and 7th Prime Minister of South Korea
Kevin Campbell – Principal Investigator for the Howard Hughes Medical Institute; internationally recognized for his contributions to muscular dystrophy research
Peter J. Denning – award-winning computer scientist best known for inventing the working-set model for program behavior, which defeated thrashing in operating systems and became the reference standard for all memory management policies
Michael J. Flynn – professor emeritus of computer science at Stanford University; recipient of Harry H. Goode Memorial Award
Edward E. Hammer – IEEE Edison Medal for fluorescent lighting research
Valery Havard – botanist for whom many Texas plants are named, including the Chisos bluebonnet (Lupinus havardii), Havard oak (Quercus havardii), and Havard's evening primrose (Oenothera havardii)
Vincent dePaul Draddy – Manhattan University quarterback who developed the Izod and Lacoste brands. College Football Hall of Famer and Chairman of the National Football Foundation. The Vincent dePaul Draddy Trophy is a trophy awarded by the National Football Foundation that is given to the American college football player with the best combination of academics, community service, and on-field performance. It is considered by many to be the "Academic Heisman."
Vic Fusia – former head football coach of the University of Massachusetts
Dick Tuckey – former professional American football running back
Pat Kirwan (football) – Receivers Coach and Personnel Assistant for the New York Jets under Pete Carroll. Currently Senior Football Analyst for the National Football League website.