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Lactic acid/citric acid/potassium bitartrate
Combination of
Lactic acid	Alpha hydroxy acid
Citric acid	Tricarboxylic acid
Potassium bitartrate	Sugar acid salt
Clinical data
Trade names	Phexxi
AHFS/Drugs.com	Multum Consumer Information
License data	US DailyMed: Phexxi;
Routes of; administration	Intravaginal
ATC code	None;
Legal status
Legal status	US: ℞-only;
Identifiers
KEGG	D12498;

Lactic acid/citric acid/potassium bitartrate, sold under the brand name Phexxi, is a non-hormonal combination medication used as a method of birth control.^[1]^[2] It contains lactic acid, citric acid, and potassium bitartrate.^[1]^[2] It is a gel inserted into the vagina.^[2]^[3]

The most common adverse reactions include vulvovaginal burning sensation, vulvovaginal pruritus, vulvovaginal mycotic infection, urinary tract infection, vulvovaginal discomfort, bacterial vaginosis, vaginal discharge, genital discomfort, dysuria, and vulvovaginal pain.^[2]

Medical uses

The combination is indicated for the prevention of pregnancy in females of reproductive potential for use as an on-demand method of contraception.^[2]

History

The combination was approved for medical use in the United States in May 2020.^[2]^[4]^[5]

References

^ ^a ^b ^c "Phexxi- lactic acid, l-, citric acid monohydrate, and potassium bitartrate gel". DailyMed. Retrieved 13 February 2022.
^ ^a ^b ^c ^d ^e ^f ^g "U.S. FDA Approves Evofem Biosciences' Phexxi (lactic acid, citric acid and potassium bitartrate), the First and Only Non-Hormonal Prescription Gel for the Prevention of Pregnancy". Evofem Biosciences (Press release). 22 May 2020. Retrieved 22 May 2020 – via PR Newswire.
^ Steinberg J, Lynch SE (May 2021). "Lactic Acid, Citric Acid, and Potassium Bitartrate (Phexxi) Vaginal Gel for Contraception". American Family Physician. 103 (10): 628–629. PMID 33982994.
^ "Phexxi: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 23 May 2020.
^ "Drug Approval Package: Phexxi". U.S. Food and Drug Administration (FDA). 3 November 2020. Retrieved 13 February 2022.

[Phexxi_FDA_label-1] "Phexxi- lactic acid, l-, citric acid monohydrate, and potassium bitartrate gel". DailyMed. Retrieved 13 February 2022.

[Phexxi_PR-2] ^ ^a ^b ^c ^d ^e ^f ^g "U.S. FDA Approves Evofem Biosciences' Phexxi (lactic acid, citric acid and potassium bitartrate), the First and Only Non-Hormonal Prescription Gel for the Prevention of Pregnancy". Evofem Biosciences (Press release). 22 May 2020. Retrieved 22 May 2020 – via PR Newswire.

[Steinberg_2021-3] Steinberg J, Lynch SE (May 2021). "Lactic Acid, Citric Acid, and Potassium Bitartrate (Phexxi) Vaginal Gel for Contraception". American Family Physician. 103 (10): 628–629. PMID 33982994.

[4] "Phexxi: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 23 May 2020.

[5] "Drug Approval Package: Phexxi". U.S. Food and Drug Administration (FDA). 3 November 2020. Retrieved 13 February 2022.

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