She was cast in the stage play Four Saints in Mexico. In 2004, Lowes landed her first screen role in the FX series Rescue Me and later co-starred opposite Marcia Gay Harden in the Showtime pilot, Hate. Lowes later guest starred in a number of television series, including The Sopranos, Without a Trace, NCIS, Ghost Whisperer, Castle, Leverage, and The Closer. In 2008, she starred opposite Laurie Metcalf in The CW short-lived comedy-drama series, Easy Money.[5][6] In addition to her television performances, Lowes appeared in a number of low-budget films, including The Job (2009), Bear (2010), and Café (2011).
With her husband, Adam Shapiro, she is one of the founders and directors of the Los Angeles-based IAMA Theater Company, and a supporter of Southern California's black box theater community.[11][12]
In July 2018, Lowes made her Broadway debut, along with her husband Shapiro, in the Broadway production of Waitress.[13] They remained in the production until October 7, 2018.[14]
On May 14, 2021, CBS announced that Lowes would star opposite Pete Holmes in a sitcom based around the life of laid-off auto worker-turned-professional bowlerTom Smallwood.[15] The multi-camera series mid-season debut was planned for the 2021–22 television season.[16] On November 24, CBS announced the sitcom had been retitled How We Roll, and received an adjusted first season order of 11 episodes.[17] On December 10, 2021, CBS announced the series would premiere on March 31, 2022.[18] In May 2022, the series was canceled after one season.
Lowes lives in Los Angeles with her husband, actor Adam Shapiro.[19] Shapiro played her character's boyfriend in an episode of Scandal.[20] In May 2017, she announced that she and her husband were expecting their first child, a boy.[21] She announced the birth of their son, Albee Shapiro, on October 5, 2017.[22] Lowes gave birth to their daughter, Vera Shapiro, on November 22, 2020.[23]
^Genn, Adina. "How Port Washington Helped Shape ABC Star Katie Lowes", Port Washington, NY, Patch, April 5, 2012. Accessed February 6, 2023. "Lowes plays Quinn Perkins, a young lawyer with a secret past and a steep learning curve. But don't be fooled by the hype. Lowes is still very much a Port Washington girl, and says her roots played a big role in who she is today.... Like many current Port Washington 'theater kids,' Lowes, who graduated high school in 2000, devoted herself to the local arts scene, and all of its opportunities."
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