In 2000, Spain won the RTÉ award for Best New Act.[1]
Spain appeared at the MontrealJust for Laughs comedy festival in 2003, which was later repeated on RTÉ Television. He is a regular at the Kilkenny Cat Laughs comedy festival.
Spain later ran a series on RTÉ entitled Karl Spain Wants a Woman.[2] He appeared as master of kung-fu on the fifth series of Killinaskully in October 2008.
In 2009 he had yet another TV show on RTÉ Two, Karl Spain wants to Rock.
In March 2010 Karl began a tour as supporting act to fellow Irish comedian, Ed Byrne.
Toured with Kevin Bridges in 2015.
Karl Spain has also been known to attend University of Limerick Comedy Nights.