Musimessi started his playing career in 1944 with Newell's Old Boys of Rosario, he played 183 times for the club before his transfer to Boca Juniors in 1953. In 1954 Boca won the league championship. He played 155 times for the club.[1]
Following Boca Juniors, Musimessi played for Deportivo Morón in the Argentine second level.[2]
Musimessi was known as "El Arquero cantor" (the singing goalkeeper) because of his performances on radio.[5] After retiring from the game he established a bar in Morón.