Segre was born in Berkeley, California, the daughter of Nina and Gino Claudio Segrè. She was raised in Philadelphia, where her father was a professor of physics at the University of Pennsylvania. Segre received her B.A. summa cum laude in mathematics from Amherst College in 1987,[8] where she later served on the board of trustees.[9] She received her Ph.D. in 1996 from the Massachusetts Institute of Technology. Segre then performed postdoctoral training in Molecular Genetics and Cell Biology at the University of Chicago (1996-2000).
Segre's laboratory studies how the epidermis interfaces between the body and the environment.[11] Using genomic methodologies, Segre studies the bacteria and microbes of the skin microbiome.[11] Segre's laboratory also develops genomic tools to track hospital-acquired infections of multi-drug resistant organisms.
[12][13]
^Johnson, Ryan C.; Deming, Clay; Conlan, Sean; Zellmer, Caroline J.; Michelin, Angela V.; Lee-Lin, Shihqueen; Thomas, Pamela J.; Park, Morgan; Weingarten, Rebecca A.; Less, John; Dekker, John P.; Frank, Karen M.; Musser, Kimberlee A.; McQuiston, John R.; Henderson, David K.; Lau, Anna F.; Palmore, Tara N.; Segre, Julia A. (2018). "Investigation of a Cluster of Sphingomonas koreensis Infections". New England Journal of Medicine. 379 (26): 2529–2539. doi:10.1056/NEJMoa1803238. PMC6322212. PMID30586509.