Isco represented Spain at various youth levels, including at the 2012 Olympics, and made his senior international debut in 2013, later taking part at the 2018 FIFA World Cup.
While still registered with the reserves, Isco made his debut with the first team on 11 November 2010, against Logroñés in the 2010–11 Copa del Rey, scoring two goals in a 4–1 home win (Paco Alcácer made his senior debut in the same fixture).[5][6] He played his first La Liga match three days later, featuring for 20 minutes in a 2–0 home win against Getafe after coming on as a substitute for Aritz Aduriz;[7] he thereafter made three further league appearances and two in the UEFA Champions League, all from the bench,[8] and helped the B-team return to the third level by scoring 15 goals in their campaign.[9][10]
Málaga
In mid-July 2011, Isco moved back to his home province and signed a five-year contract with Málaga after the club activated his buy-out clause of €6 million.[11] He scored his first goal for his new team on 21 November 2011, starting in a 3–1 away win against Racing de Santander;[12] he netted again the following week in a 2–1 win against Villarreal,[13] and finished his first season with 32 games and five goals as the side qualified for the UEFA Champions League for the first time in its history.
On 18 September 2012, in Málaga's first game in the Champions League group stage, Isco netted twice in a 3–0 home win over Zenit, also being chosen as Man of the Match.[14] On 22 December he scored the first goal in an eventual 3–2 win against Real Madrid at La Rosaleda, leading the locals to their first victory over that opponent in 29 years;[15] in December he won the Golden Boy award, beating Stephan El Shaarawy and Thibaut Courtois.[16][17]
On 28 January 2013, Isco ended speculation regarding his future by signing a new contract with Málaga – his new buyout clause was set at €35 million.[18] He scored his eleventh goal of the campaign on 13 March, netting the opener in a 2–0 home win against Porto, good enough for last-eight qualification after the 0–1 first leg loss at the Estádio do Dragão.[19][20]
Real Madrid
On 17 June 2013, Isco confirmed that he had received offers from Real Madrid and former Málaga manager Manuel Pellegrini's Manchester City, but stated he would only make a final decision on his future after the UEFA European Under-21 Championship final.[21] On 26 June, Real Madrid president Florentino Pérez confirmed that a deal had been reached with the player and that he would be presented by the club next week, once he passed his medical;[22] the following day he signed a five-year contract, with Real Madrid paying €30 million for his services, thus becoming the first signing of newly appointed manager Carlo Ancelotti.[23]
On 18 August 2013 Isco made his official debut for the Merengues, recording an assist and scoring the winning goal in a 2–1 home win over Real Betis, the latter coming through an 85th-minute header.[24] He continued with his form by netting two goals against Athletic Bilbao on 1 September (3–1, also at the Santiago Bernabéu).[25]
In spite of continuing to score regularly when featured, Isco received limited opportunities in the first team due to the 4–3–3 formation not being suited for his style, but Ancelotti stated that it was "a temporary problem".[26] He scored 11 goals in 53 official games in his first season, including 61 minutes in the Champions League final, a 4–1 win over Atlético Madrid in Lisbon.[27]
Prior to the start of the 2015–16 season, Isco switched his shirt number from 23 to 22, which he had previously worn at Málaga.[31] On 21 November 2015, as Real lost 0–4 at home to Barcelona in El Clásico, he was sent off in the 84th minute for a foul on Neymar.[32] He scored twice on 2 December, as the team won 3–1 at Cádiz in the first leg of the last 32 of the domestic cup.[33] Isco was a part-time starter when the team won the 2015–16 UEFA Champions League defeating Atlético Madrid 5–3 on penalties in the final played at the San Siro in Milan, Italy.[34]
On 8 August 2017, Isco scored a goal in the 2017 UEFA Super Cup, contributing to Real Madrid's 2–1 victory against Manchester United. His performance earned him the man of the match award.[38] In September 2017, he signed a new deal with Real Madrid until June 2022.[39] During the 2017–18 UEFA Champions League, he made eleven appearances, when Madrid won their third consecutive and 13th overall Champions League title as they beat Liverpool 3–1 in Kyiv.[40] He made 23 appearances during the league season, as Real Madrid won the 2019–20 La Liga.[41] In the 2021–22 season he was not an important player under Carlo Ancelotti as Real Madrid triumphed in 2021–22 La Liga and the 2021–22 UEFA Champions League. On 30 May 2022, Isco confirmed on social media that he was leaving the club after nine years.[42][43]
Sevilla
On 7 August 2022, Sevilla announced that the club reached an agreement in principle for the signing of Isco, with the player agreeing to a two-year contract.[44] On 21 December 2022, Isco and Sevilla agreed to terminate their contract.[45] On 22 December, Sevilla coach Jorge Sampaoli said Isco "did not meet the club's expectations".[46]
In the January transfer window, Isco came close to signing with Bundesliga club Union Berlin. However, on 31 January 2023, the deal collapsed, despite him passing medical tests, as the German club claimed that he made new demands that differed from the original agreement.[47] However Isco’s representatives also claimed that Union Berlin has amended the contract the moment before Isco was going to sign it, in terms of both sporting terms and salary.[citation needed]
Betis
On 26 July 2023, Isco joined Real Betis on a one-year deal.[48] On 13 August 2023, during the opening matchday of La Liga, Isco played his first game for Betis, facing off against Villarreal.[49] Later, on 28 August, he netted his first goal for Betis when they played against Athletic Bilbao, marking an end to his year-long absence from the scoresheet. However, despite his goal, Betis suffered a 4–2 defeat.[50]
On 28 December 2023, Isco extended his contract with Betis until June 2027.[51] In the 2023–24 season, he was the player with most man of the match awards in La Liga in 19 occasions.[52]
On 28 February 2012, Isco was called to the Spain under-23s team for a friendly against Egypt, but did not leave the bench.[53] On 15 May he was picked for the first time to the senior team for friendlies with Serbia and South Korea, but took no part in either match. In July, he went with the under-23 team to the Olympics in London,[54] starting all of Spain's matches as they were eliminated without scoring a goal.
On 6 February 2013, Isco made his debut with the main squad, playing the last 30 minutes in a 3–1 win over Uruguay in Doha, Qatar.[55] Also that year he appeared at the UEFA European Under-21 Championship in Israel, he scored in the final and finished the competition with the Bronze Boot (3 Goals) and made the team of the tournament as a key player for the eventual winners.[56][57]
Isco scored his first hat-trick for Spain on 27 March 2018, netting three goals against Argentina in a 6–1 friendly win.[59]
In May 2018, he was named in Spain's final squad for the 2018 FIFA World Cup.[60] He scored his first and only goal in the last group stage match against Morocco, in an eventual 2–2 draw. His goal helped the team to qualify to the second round as group winners.[61]
In May 2021, Isco was omitted from Spain's 26-man squad for UEFA Euro 2020.[62]
A quick, skillful and creative player, with excellent technique and ball control, Isco is known for his natural ability to pick out an inch-perfect pass, dribble effortlessly through two or three challenges or drift a shot into the top corner of the goal.[65][66][67] His one-step-ahead reading of the game, his anticipation of space and the general directing of his side's performances are his most common traits.
In 2013, Isco was credited by Marca journalist Pablo Polo as being "the most promising young player in Spanish football", comparing his strength, skill, and low centre of gravity to Sergio Agüero, and his vision and passing abilities to Zinedine Zidane.[68] Former Real Madrid captain Iker Casillas predicted in 2015 that Isco would become Spain's most important player.[69][70]
^"Isco, ganador del prestigioso Golden Boy" [Isco, winner of prestigious Golden Boy award] (in Spanish). Málaga's official website. 22 December 2012. Retrieved 4 April 2013.