Sullivan was born May 1, 1931, in Washington, D.C..[3] His father taught him to play the trumpet beginning at age 31⁄2, and his mother taught him saxophone. He played in 1950s Chicago with such musicians as Charlie Parker, Lester Young, Wardell Gray and Roy Eldridge, gaining a reputation as a fearsome bebop soloist. After playing briefly with Art Blakey in 1956, and mastering alto and baritone saxophone, Sullivan moved south to Florida and out of the spotlight in the early 1960s.[3]
His reluctance to travel limited his opportunities to play with musicians of the first rank, but Sullivan continued to play in the Miami area, often in schools and churches. Contact with local younger players such as Jaco Pastorius and Pat Metheny led to teaching and to a broadening of his own musical roots to include the stylings of John Coltrane's jazz.[3]
With the addition of flute and soprano saxophone to his performing range, Sullivan moved to New York, and in 1980 formed a quintet with bop trumpeter Red Rodney. Sullivan and Rodney worked on new material and fostered young talent.[3]
Sullivan and his longtime friend and collaborator Stu Katz, jazz pianist and vibraphonist, co-led a multi-night performance with Katz at Joe Segal's The Jazz Showcase in Chicago. A live recording of some of those performances, A Family Affair: Live At Joe Segal's Jazz Showcase, was released in 2011.
Ira Sullivan's musical signature was "Amazing Grace", the tune with which he closed every performance for decades. In the week following Sullivan's death, the jazz community produced a Love Letter to Ira Sullivan, a compilation of more than forty performances of "Amazing Grace".[4]