Intragenomic conflict

Intragenomic conflict refers to the evolutionary phenomenon where genes have phenotypic effects that promote their own transmission in detriment of the transmission of other genes that reside in the same genome.^[1][2][3][4] The selfish gene theory postulates that natural selection will increase the frequency of those genes whose phenotypic effects cause their transmission to new organisms, and most genes achieve this by cooperating with other genes in the same genome to build an organism capable of reproducing and/or helping kin to reproduce.^[5] The assumption of the prevalence of intragenomic cooperation underlies the organism-centered concept of inclusive fitness. However, conflict among genes in the same genome may arise both in events related to reproduction (a selfish gene may "cheat" and increase its own presence in gametes or offspring above the expected according to fair Mendelian segregation and fair gametogenesis) and altruism (genes in the same genome may disagree on how to value other organisms in the context of helping kin because coefficients of relatedness diverge between genes in the same genome).^[6][7][8]

Nuclear genes

Autosomic genes usually have the same mode of transmission in sexually reproducing species due to the fairness of Mendelian segregation, but conflicts among alleles of autosomic genes may arise when an allele cheats during gametogenesis (segregation distortion) or eliminates embryos that do not contain it (lethal maternal effects). An allele may also directly convert its rival allele into a copy of itself (homing endonucleases). Finally, mobile genetic elements completely bypass Mendelian segregation, being able to insert new copies of themselves into new positions in the genome (transposons).

Segregation distortion

In principle, the two parental alleles have equal probabilities of being present in the mature gamete. However, there are several mechanisms that lead to an unequal transmission of parental alleles from parents to offspring. One example is a gene drive complex, called a segregation distorter, that "cheats" during meiosis or gametogenesis and thus is present in more than half of the functional gametes. The most studied examples are sd in Drosophila melanogaster (fruit fly),^[9] t haplotype in Mus musculus (mouse) and sk in Neurospora spp. (fungus). Possible examples have also been reported in humans.^[10] Segregation distorters that are present in sexual chromosomes (as is the case with the X chromosome in several Drosophila species^[11][12]) are denominated sex-ratio distorters, as they induce a sex-ratio bias in the offspring of the carrier individual.

Killer and target

The simplest model of meiotic drive involves two tightly linked loci: a Killer locus and a Target locus. The segregation distorter set is composed by the allele Killer (in the Killer locus) and the allele Resistant (in the Target locus), while its rival set is composed by the alleles Non-killer and Non-resistant. So, the segregation distorter set produces a toxin to which it is itself resistant, while its rival is not. Thus, it kills those gametes containing the rival set and increases in frequency. The tight linkage between these loci is crucial, so these genes usually lie on low-recombination regions of the genome.

True meiotic drive

Other systems do not involve gamete destruction, but rather use the asymmetry of meiosis in females: the driving allele ends up in the oocyte instead of in the polar bodies with a probability greater than one half. This is termed true meiotic drive, as it does not rely on a post-meiotic mechanism. The best-studied examples include the neocentromeres (knobs) of maize, as well as several chromosomal rearrangements in mammals. The general molecular evolution of centromeres is likely to involve such mechanisms.

Lethal maternal effects

Main article: Maternal effect dominant embryonic arrest

The Medea gene causes the death of progeny from a heterozygous mother that do not inherit it. It occurs in the flour beetle (Tribolium castaneum).^[13] Maternal-effect selfish genes have been successfully synthesized in the lab.^[14]

Transposons

Transposons are autonomous replicating genes that encode the ability to move to new positions in the genome and therefore accumulate in the genomes. They replicate themselves in spite of being detrimental to the rest of the genome. They are often called 'jumping genes' or parasitic DNA and were discovered by Barbara McClintock in 1944.

Homing endonuclease genes

Main article: Homing endonucleases

Homing endonuclease genes (HEG) convert their rival allele into a copy of themselves, and are thus inherited by nearly all meiotic daughter cells of a heterozygote cell. They achieve this by encoding an endonuclease which breaks the rival allele. This break is repaired by using the sequence of the HEG as template.^[15]

HEGs encode sequence-specific endonucleases. The recognition sequence (RS) is 15–30 bp long and usually occurs once in the genome. HEGs are located in the middle of their own recognition sequences. Most HEGs are encoded by self-splicing introns (group I & II) and inteins. Inteins are internal protein fragments produced from protein splicing and usually contain endonuclease and splicing activities. The allele without the HEGs are cleaved by the homing endonuclease and the double-strand break are repaired by homologous recombination (gene conversion) using the allele containing HEGs as template. Both chromosomes will contain the HEGs after repair.^[16]

B-chromosome

B-chromosomes are nonessential chromosomes; not homologous with any member of the normal (A) chromosome set; morphologically and structurally different from the As; and they are transmitted at higher-than-expected frequencies, leading to their accumulation in progeny. In some cases, there is strong evidence to support the contention that they are simply selfish and that they exist as parasitic chromosomes.^[17] They are found in all major taxonomic groupings of both plants and animals.

Cytoplasmic genes

Since nuclear and cytoplasmic genes usually have different modes of transmission, intragenomic conflicts between them may arise.^[18] Mitochondria and chloroplasts are two examples of sets of cytoplasmic genes that commonly have exclusive maternal inheritance, similar to endosymbiont parasites in arthropods, like Wolbachia.^[19]

Males as dead-ends to cytoplasmic genes

Anisogamy generally produces zygotes that inherit cytoplasmic elements exclusively from the female gamete. Thus, males represent dead-ends to these genes. Because of this fact, cytoplasmic genes have evolved a number of mechanisms to increase the production of female descendants and eliminate offspring not containing them.^[20]

Feminization

Male organisms are converted into females by cytoplasmic inherited protists (Microsporidia) or bacteria (Wolbachia), regardless of nuclear sex-determining factors. This occurs in amphipod and isopod Crustacea and Lepidoptera.

Male-killing

Male embryos (in the case of cytoplasmic inherited bacteria) or male larvae (in the case of Microsporidia) are killed. In the case of embryo death, this diverts investment from males to females who can transmit these cytoplasmic elements (for instance, in ladybird beetles, infected female hosts eat their dead male brothers, which is positive from the viewpoint of the bacterium). In the case of microsporidia-induced larval death, the agent is transmitted out of the male lineage (through which it cannot be transmitted) into the environment, where it may be taken up again infectiously by other individuals. Male-killing occurs in many insects. In the case of male embryo death, a variety of bacteria have been implicated, including Wolbachia.

Male-sterility

In some cases anther tissue (male gametophyte) is killed by mitochondria in monoecious angiosperms, increasing energy and material spent in developing female gametophytes. This leads to a shift from monoecy to gynodioecy, where part of the plants in the population are male-sterile.

Parthenogenesis induction

In certain haplodiploid Hymenoptera and mites, in which males are produced asexually, Wolbachia and Cardinium can induce duplication of the chromosomes and thus convert the organisms into females. The cytoplasmic bacterium forces haploid cells to go through incomplete mitosis to produce diploid cells which therefore will be female. This produces an entirely female population. If antibiotics are administered to populations which have become asexual in this way, they revert to sexuality instantly, as the cytoplasmic bacteria forcing this behaviour upon them are removed.

Cytoplasmic incompatibility

In many arthropods, zygotes produced by sperm of infected males and ova of non-infected females can be killed by Wolbachia or Cardinium.^[19]

Evolution of sex

Conflict between chromosomes has been proposed as an element in the evolution of sex.^[21]

See also

• Green-beard effect

References

1. Gardner, Andy; Úbeda, Francisco (6 November 2017). "The meaning of intragenomic conflict". Nature Ecology & Evolution. 1 (12): 1807–1815. doi:10.1038/s41559-017-0354-9. hdl:10023/13307. PMID 29109471. S2CID 3314539.
2. Austin., Burt (2006). Genes in conflict : the biology of selfish genetic elements. Trivers, Robert. Cambridge, MA: Belknap Press of Harvard University Press. ISBN 9780674027220. OCLC 647823687.
3. Spencer, Hamish G (2003). "Intragenomic Conflict". Encyclopedia of Life Sciences. John Wiley & Sons, Ltd. doi:10.1038/npg.els.0001714. ISBN 9780470015902. {{cite book}}: |work= ignored (help)
4. Hurst, Laurence D.; Atlan, Anne; Bengtsson, Bengt O. (September 1996). "Genetic Conflicts". The Quarterly Review of Biology. 71 (3): 317–364. doi:10.1086/419442. PMID 8828237. S2CID 24853836.
5. Dawkins, Richard (1976). The selfish gene. New York: Oxford University Press. ISBN 978-0198575191. OCLC 2681149.
6. Ågren, J. Arvid (December 2016). "Selfish genetic elements and the gene's-eye view of evolution". Current Zoology. 62 (6): 659–665. doi:10.1093/cz/zow102. PMC 5804262. PMID 29491953.
7. Werren, J. H. (20 June 2011). "Selfish genetic elements, genetic conflict, and evolutionary innovation". Proceedings of the National Academy of Sciences. 108 (Supplement_2): 10863–10870. Bibcode:2011PNAS..10810863W. doi:10.1073/pnas.1102343108. PMC 3131821. PMID 21690392.
8. Rice, William R. (23 November 2013). "Nothing in Genetics Makes Sense Except in Light of Genomic Conflict". Annual Review of Ecology, Evolution, and Systematics. 44 (1): 217–237. doi:10.1146/annurev-ecolsys-110411-160242.
9. Larracuente, Amanda M.; Presgraves, Daven C. (1 September 2012). "The Selfish Segregation Distorter Gene Complex of Drosophila melanogaster". Genetics. 192 (1): 33–53. doi:10.1534/genetics.112.141390. PMC 3430544. PMID 22964836.
10. Yang, Liu; Liangliang Zhang; Shuhua Xu; Landian Hu; Laurence D. Hurst; Xiangyin Kong (July 2013). "Identification of Two Maternal Transmission Ratio Distortion Loci in Pedigrees of the Framingham Heart Study". Scientific Reports. 3: 2147. Bibcode:2013NatSR...3.2147L. doi:10.1038/srep02147. PMC 3701898. PMID 23828458.
11. ""Sex Ratio" Meiotic Drive in Drosophila testacea" (PDF).
12. Sturtevant AH, Dobzhansky T (Jul 1936). "Geographical Distribution and Cytology of "Sex Ratio" in Drosophila Pseudoobscura and Related Species". Genetics. 21 (4): 473–90. doi:10.1093/genetics/21.4.473. PMC 1208687. PMID 17246805.
13. R. W. Beeman; K. S. Friesen; R. E. Denell (1992). "Maternal-effect selfish genes in flour beetles" (PDF). Science. 256 (5053): 89–92. Bibcode:1992Sci...256...89B. doi:10.1126/science.1566060. PMID 1566060. Archived from the original (PDF) on 2012-03-13. Retrieved 2011-07-21.
14. Chen, Chun-Hong; Huang, Haixia; Ward, Catherine M.; Su, Jessica T.; Schaeffer, Lorian V.; Guo, Ming; Hay, Bruce A. (27 April 2007). "A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila". Science. 316 (5824). American Association for the Advancement of Science (AAAS): 597–600. doi:10.1126/science.1138595. ISSN 0036-8075. PMID 17395794. S2CID 245885832.
15. Steven P. Sinkins; Fred Gould (2006). "Gene drive systems for insect disease vectors" (PDF). Nature Reviews Genetics. 7 (6): 427–435. doi:10.1038/nrg1870. PMID 16682981. S2CID 17405210. Archived from the original (PDF) on 2016-03-04. Retrieved 2011-07-21.
16. Austin Burt; Vassiliki Koufopanou (2004). "Homing endonuclease genes: the rise and fall and rise again of a selfish element". Current Opinion in Genetics & Development. 14 (6): 609–615. doi:10.1016/j.gde.2004.09.010. PMID 15531154.
17. Östergren, G. (1947). "Heterochromatic B-Chromosomes in Anthoxanthum". Hereditas. 33 (1–2): 261–296. doi:10.1111/j.1601-5223.1947.tb02804.x.
18. Murlas Cosmides, Leda; Tooby, John (March 1981). "Cytoplasmic inheritance and intragenomic conflict". Journal of Theoretical Biology. 89 (1): 83–129. Bibcode:1981JThBi..89...83M. doi:10.1016/0022-5193(81)90181-8. PMID 7278311.
19. Duron, Olivier; Bouchon, Didier; Boutin, Sébastien; Bellamy, Lawrence; Zhou, Liqin; Engelstädter, Jan; Hurst, Gregory D (24 June 2008). "The diversity of reproductive parasites among arthropods: Wolbachiado not walk alone". BMC Biology. 6 (1): 27. doi:10.1186/1741-7007-6-27. PMC 2492848. PMID 18577218.
20. Jan Engelstädter; Gregory D. D. Hurst (2009). "The ecology and evolution of microbes that manipulate host reproduction". Annual Review of Ecology, Evolution, and Systematics. 140: 127–149. doi:10.1146/annurev.ecolsys.110308.120206.
21. Julian D. O'Dea (2006). "Did conflict between chromosomes drive the evolution of sex?". Calodema. 8: 33–34. See also [1].

Further reading

• Burt, A. & R. L. Trivers (2006). Genes in Conflict: the Biology of Selfish Genetic Elements. Harvard: Belknap Press. ISBN 978-0-674-01713-9.
• Cosmides, L. M. & J. Tooby (1981). "Cytoplasmic inheritance and intragenomic conflict". Journal of Theoretical Biology. 89 (1): 83–129. Bibcode:1981JThBi..89...83M. CiteSeerX 10.1.1.140.5960. doi:10.1016/0022-5193(81)90181-8. PMID 7278311.
• Dawkins, R. (1976). The Selfish Gene. Oxford: Oxford University Press. ISBN 978-0-19-217773-5.
• Eberhard, W. G. (1980). "Evolutionary consequences of intracellular organelle competition" (PDF). The Quarterly Review of Biology. 55 (3): 231–249. doi:10.1086/411855. JSTOR 2824738. PMID 7208806. S2CID 39165525.
• Haig, D. (1997). "The social gene". In J. R. Krebs, & N. B. Davies (ed.). Behavioural Ecology: an Evolutionary Approach (4th ed.). London: Blackwell Publishers. pp. 284–304. ISBN 978-0-86542-731-0.
• Hurst, Laurence D.; Atlan, Anne; Bengtsson, Bengt O. (1996). "Genetic Conflicts". The Quarterly Review of Biology. 71 (3). University of Chicago Press: 317–364. doi:10.1086/419442. ISSN 0033-5770. PMID 8828237. S2CID 24853836.
• Hurst, G. D. D.; J. H. Werren (2001). "The role of selfish genetic elements in eukaryotic evolution". Nature Reviews Genetics. 2 (8): 597–606. CiteSeerX 10.1.1.77.9286. doi:10.1038/35084545. PMID 11483984. S2CID 2715605.
• Jones, R. N. (1991). "B-chromosome drive". The American Naturalist. 137 (3): 430–442. doi:10.1086/285175. JSTOR 2462577. S2CID 83712596.