Hysterectomy is the surgical removal of the uterus and cervix. Supracervical hysterectomy refers to removal of the uterus while the cervix is spared. These procedures may also involve removal of the ovaries (oophorectomy), fallopian tubes (salpingectomy), and other surrounding structures. The term “partial” or “total” hysterectomy are lay-terms that incorrectly describe the addition or omission of oophorectomy at the time of hysterectomy. These procedures are usually performed by a gynecologist. Removal of the uterus renders the patient unable to bear children (as does removal of ovaries and fallopian tubes) and has surgical risks as well as long-term effects, so the surgery is normally recommended only when other treatment options are not available or have failed. It is the second most commonly performed gynecological surgical procedure, after cesarean section, in the United States.[1] Nearly 68 percent were performed for conditions such as endometriosis, irregular bleeding, and uterine fibroids.[1] It is expected that the frequency of hysterectomies for non-malignant indications will continue to fall given the development of alternative treatment options.[2]
Medical uses
Hysterectomy is a major surgical procedure that has risks and benefits. It affects the hormonal balance and overall health of patients. Because of this, hysterectomy is normally recommended as a last resort after pharmaceutical or other surgical options have been exhausted to remedy certain intractable and severe uterine/reproductive system conditions. There may be other reasons for a hysterectomy to be requested. Such conditions and/or indications include, but are not limited to:[3]
Endometriosis: growth of the uterine lining outside the uterine cavity. This inappropriate tissue growth can lead to pain and bleeding.[4]
Adenomyosis: a form of endometriosis, where the uterine lining has grown into and sometimes through the uterine wall musculature. This can thicken the uterine walls and also contribute to pain and bleeding.[5]
Heavy menstrual bleeding: irregular or excessive menstrual bleeding for greater than a week. It can disturb regular quality of life and may be indicative of a more serious condition.
Uterine fibroids: benign growths on the uterus wall. These muscular noncancerous tumors can grow in single form or in clusters and can cause extreme pain and bleeding.[6]
Uterine prolapse: when the uterus sags down due to weakened or stretched pelvic floor muscles potentially causing the uterus to protrude out of the vagina in more severe cases.
Reproductive system cancer prevention: especially if there is a strong family history of reproductive system cancers (especially breast cancer in conjunction with BRCA1 or BRCA2 mutation), or as part of recovery from such cancers.[7]
Gynecologic cancer: depending on the type of hysterectomy, can aid in treatment of cancer or precancer of the endometrium, cervix, or uterus. In order to protect against or treat cancer of the ovaries, would need an oophorectomy.
Transgender (trans) male affirmation: aids in gender dysphoria, prevention of future gynecologic problems, and transition to obtaining new legal gender documentation.[8]
Severe developmental disabilities: this treatment is controversial at best. In the United States, specific cases of sterilization due to developmental disabilities have been found by state-level Supreme Courts to violate the patient's constitutional and common-law rights.[9]
Postpartum: to remove either a severe case of placenta praevia (a placenta that has either formed over or inside the birth canal) or placenta percreta (a placenta that has grown into and through the wall of the uterus to attach itself to other organs), as well as a last resort in case of excessive obstetrical haemorrhage.[10]
Chronic pelvic pain: should try to obtain pain etiology, although may have no known cause.[11]
PMS and menstrual pain and other psychic and physical conditions caused by menstrual period and causing suffering and diminishing life quality
Childfree, in order to prevent problems caused by uterus and uselessness of reproductive function
Risks and adverse effects
In 1995, the short-term mortality (within 40 days of surgery) was reported at 0.38 cases per 1000 when performed for benign causes. Risks for surgical complications were presence of fibroids, younger age (vascular pelvis with higher bleeding risk and larger uterus), dysfunctional uterine bleeding and parity.[12]
The mortality rate is several times higher when performed in patients who are pregnant, have cancer or other complications.[13]
Long-term effect on all case mortality is relatively small. Women under the age of 45 years have a significantly increased long-term mortality that is believed to be caused by the hormonal side effects of hysterectomy and prophylactic oophorectomy.[14][15] This effect is not limited to pre-menopausal women; even women who have already entered menopause were shown to have experienced a decrease in long-term survivability post-oophorectomy.[16]
Approximately 35% of women after hysterectomy undergo another related surgery within 2 years.[17]
Ureteral injury is not uncommon and occurs in 0.2 per 1,000 cases of vaginal hysterectomy and 1.3 per 1,000 cases of abdominal hysterectomy.[18] The injury usually occurs in the distal ureter close to the infundibulopelvic ligament or as a ureter crosses below the uterine artery, often from blind clamping and ligature placement to control hemorrhage.[19]
Recovery
Hospital stay is 3 to 5 days or more for the abdominal procedure and between 1 and 2 days (but possibly longer) for vaginal or laparoscopically assisted vaginal procedures.[20] After the procedure, the American College of Obstetricians and Gynecologists recommends not inserting anything into the vagina for the first 6 weeks (including inserting tampons or having sex).[21]
Unintended oophorectomy and premature ovarian failure
Removal of one or both ovaries is performed in a substantial number of hysterectomies that were intended to be ovary sparing.[22]
The average onset age of menopause after hysterectomy with ovarian conservation is 3.7 years earlier than average.[23] This has been suggested to be due to the disruption of blood supply to the ovaries after a hysterectomy or due to missing endocrine feedback of the uterus. The function of the remaining ovaries is significantly affected in about 40% of people, some of them even require hormone replacement therapy. Surprisingly, a similar and only slightly weaker effect has been observed for endometrial ablation which is often considered as an alternative to hysterectomy.[24]
A substantial number of women develop benign ovarian cysts after a hysterectomy.[25]
Effects on sexual life and pelvic pain
After hysterectomy for benign indications the majority of patients report improvement in sexual life and pelvic pain. A smaller share of patients report worsening of sexual life and other problems. The picture is significantly different for hysterectomy performed for malignant reasons; the procedure is often more radical with substantial side effects.[26][27] A proportion of patients who undergo a hysterectomy for chronic pelvic pain continue to have pelvic pain after a hysterectomy and develop dyspareunia (painful sexual intercourse).[28]
Premature menopause and its effects
Estrogen levels fall sharply when the ovaries are removed, removing the protective effects of estrogen on the cardiovascular and skeletal systems. This condition is often referred to as "surgical menopause", although it is substantially different from a naturally occurring menopausal state; the former is a sudden hormonal shock to the body that causes rapid onset of menopausal symptoms such as hot flashes, while the latter is a gradually occurring decrease of hormonal levels over a period of years with uterus intact and ovaries able to produce hormones even after the cessation of menstrual periods.[29]
One study showed that risk of subsequent cardiovascular disease is substantially increased for women who had hysterectomy at age 50 or younger. No association was found for women undergoing the procedure after age 50. The risk is higher when ovaries are removed but still noticeable even when ovaries are preserved.[30]
Several other studies have found that osteoporosis (decrease in bone density) and increased risk of bone fractures are associated with hysterectomies.[31][32] This has been attributed to the modulatory effect of estrogen on calcium metabolism and the drop in serum estrogen levels after menopause can cause excessive loss of calcium leading to bone wasting.
Hysterectomies have also been linked with higher rates of heart disease and weakened bones. Those who have undergone a hysterectomy with both ovaries removed typically have reduced testosterone levels as compared to those left intact.[22] Reduced levels of testosterone in women are predictive of height loss, which may occur as a result of reduced bone density,[33] while increased testosterone levels in women are associated with a greater sense of sexual desire.[34]
Oophorectomy before the age of 45 is associated with a fivefold mortality from neurologic and mental disorders.[35]
Urinary incontinence and vaginal prolapse
Urinary incontinence and vaginal prolapse are well known adverse effects that develop with high frequency a very long time after the surgery. Typically, those complications develop 10–20 years after the surgery.[36] For this reason exact numbers are not known, and risk factors are poorly understood. It is also unknown if the choice of surgical technique has any effect. It has been assessed that the risk for urinary incontinence is approximately doubled within 20 years after hysterectomy. One long-term study found a 2.4 fold increased risk for surgery to correct urinary stress incontinence following hysterectomy.[37][38]
The risk for vaginal prolapse depends on factors such as number of vaginal deliveries, the difficulty of those deliveries, and the type of labor.[39] Overall incidence is approximately doubled after hysterectomy.[40]
Adhesion formation and bowel obstruction
The formation of postoperative adhesions is a particular risk after hysterectomy because of the extent of dissection involved as well as the fact the hysterectomy wound is in the most gravity-dependent part of the pelvis into which a loop of bowel may easily fall.[41] In one review, incidence of small bowel obstruction due to intestinal adhesion was found to be 15.6% in non-laparoscopic total abdominal hysterectomies vs. 0.0% in laparoscopic hysterectomies.[42]
Wound infection
Wound infection occurs in approximately 3% of cases of abdominal hysterectomy. The risk is increased by obesity, diabetes, immunodeficiency disorder, use of systemic corticosteroids, smoking, wound hematoma, and preexisting infection such as chorioamnionitis and pelvic inflammatory disease.[43] Such wound infections mainly take the form of either incisional abscess or wound cellulitis. Typically, both confer erythema, but only an incisional abscess confers purulent drainage. The recommended treatment of an incisional abscess after hysterectomy is by incision and drainage, and then coverage by a thin layer of gauze followed by sterile dressing. The dressing should be changed and the wound irrigated with normal saline at least twice each day. In addition, it is recommended to administer an antibiotic active against staphylococci and streptococci, preferably vancomycin when there is a risk of MRSA.[43] The wound can be allowed to close by secondary intention. Alternatively, if the infection is cleared and healthy granulation tissue is evident at the base of the wound, the edges of the incision may be reapproximated, such as by using butterfly stitches, staples or sutures.[43] Sexual intercourse remains possible after hysterectomy. Reconstructive surgery remains an option for women who have experienced benign and malignant conditions.[44]: 1020–1348
Other rare problems
Hysterectomy may cause an increased risk of the relatively rare renal cell carcinoma. The increased risk is particularly pronounced for young women; the risk was lower after vaginally performed hysterectomies.[45] Hormonal effects or injury of the ureter were considered as possible explanations.[46][47] In some cases the renal cell carcinoma may be a manifestation of an undiagnosed hereditary leiomyomatosis and renal cell cancer syndrome.
Removal of the uterus without removing the ovaries can produce a situation that on rare occasions can result in ectopic pregnancy due to an undetected fertilization that had yet to descend into the uterus before surgery. Two cases have been identified and profiled in an issue of the Blackwell Journal of Obstetrics and Gynecology; over 20 other cases have been discussed in additional medical literature.[48] On very rare occasions, sexual intercourse after hysterectomy may cause a transvaginal evisceration of the small bowel.[49] The vaginal cuff is the uppermost region of the vagina that has been sutured closed. A rare complication, it can dehisce and allow the evisceration of the small bowel into the vagina.[50]
Alternatives
Depending on the indication there are alternatives to hysterectomy:
Menorrhagia (heavy or abnormal menstrual bleeding) may also be treated with the less invasive endometrial ablation which is an outpatient procedure in which the lining of the uterus is destroyed with heat, mechanically or by radio frequency ablation.[52] Endometrial ablation greatly reduces or eliminates monthly bleeding in ninety percent of patients with DUB. It is not effective for patients with very thick uterine lining or uterine fibroids.[53]
Levonorgestrel intrauterine devices are highly effective in limiting menstrual blood flow and improving other symptoms. Side effects are typically very moderate because the levonorgestrel (a progestin) is released in low concentration locally. There is now substantial evidence that Levongestrel-IUDs provide good symptomatic relief for women with fibroids.[54]
Uterine fibroids may be removed and the uterus reconstructed in a procedure called "myomectomy". A myomectomy may be performed through an open incision, laparoscopically, or through the vagina (hysteroscopy).[55]
Uterine artery embolization (UAE) is a minimally invasive procedure for treatment of uterine fibroids. Under local anesthesia a catheter is introduced into the femoral artery at the groin and advanced under radiographic control into the uterine artery. A mass of microspheres or polyvinyl alcohol (PVA) material (an embolus) is injected into the uterine arteries in order to block the flow of blood through those vessels.[56] The restriction in blood supply usually results in significant reduction of fibroids and improvement of heavy bleeding tendency. The 2012 Cochrane review comparing hysterectomy and UAE did not find any major advantage for either procedure. While UAE is associated with shorter hospital stay and a more rapid return to normal daily activities, it was also associated with a higher risk for minor complications later on. There were no differences between UAE and hysterectomy with regards to major complications.[57]
Prolapse may also be corrected surgically without removal of the uterus.[58] There are several strategies that can be utilized to help strengthen pelvic floor muscles and prevent the worsening of prolapse. These include, but are not limited to, use of "kegel exercises", vaginal pessary, constipation relief, weight management, and care when lifting heavy objects.[59]
Types
Hysterectomy, in the literal sense of the word, means merely removal of the uterus. However other organs such as ovaries, fallopian tubes, and the cervix are very frequently removed as part of the surgery.[60]
Radical hysterectomy: complete removal of the uterus, cervix, upper vagina, and parametrium. Indicated for cancer. Lymph nodes, ovaries, and fallopian tubes are also usually removed in this situation, such as in Wertheim's hysterectomy.[61]
Total hysterectomy: complete removal of the uterus and cervix, with or without oophorectomy.
Subtotal hysterectomy: removal of the uterus, leaving the cervix in situ.
Subtotal (supracervical) hysterectomy was originally proposed with the expectation that it may improve sexual functioning after hysterectomy, it has been postulated that removing the cervix causes excessive neurologic and anatomic disruption, thus leading to vaginal shortening, vaginal vault prolapse, and vaginal cuff granulations.[62] These theoretical advantages were not confirmed in practice, but other advantages over total hysterectomy emerged. The principal disadvantage is that risk of cervical cancer is not eliminated and women may continue cyclical bleeding (although substantially less than before the surgery).
These issues were addressed in a systematic review of total versus supracervical hysterectomy for benign gynecological conditions, which reported the following findings:[63]
There was no difference in the rates of incontinence, constipation, measures of sexual function, or alleviation of pre-surgery symptoms.
Length of surgery and amount of blood lost during surgery were significantly reduced during supracervical hysterectomy compared to total hysterectomy, but there was no difference in post-operative transfusion rates.[64]
Febrile morbidity was less likely and ongoing cyclic vaginal bleeding one year after surgery was more likely after supracervical hysterectomy.
There was no difference in the rates of other complications, recovery from surgery, or readmission rates.
In the short-term, randomized trials have shown that cervical preservation or removal does not affect the rate of subsequent pelvic organ prolapse.[65]
Supracervical hysterectomy does not eliminate the possibility of having cervical cancer since the cervix itself is left intact and may be contraindicated in women with increased risk of this cancer; regular pap smears to check for cervical dysplasia or cancer are still needed.[66][67]
Technique
Hysterectomy can be performed in different ways. The oldest known technique is vaginal hysterectomy. The first planned hysterectomy was performed by Konrad Johann Martin Langenbeck - Surgeon General of the Hannovarian army, although there are records of vaginal hysterectomy for prolapse going back as far as 50BC.[68]
The first abdominal hysterectomy recorded was by Ephraim McDowell. He performed the procedure in 1809 for a mother of five for a large ovarian mass on her kitchen table.[69]
In modern medicine today, laparoscopic vaginal (with additional instruments passing through ports in small abdominal incisions, close or in the navel) and total laparoscopic techniques have been developed.
Abdominal hysterectomy
Most hysterectomies in the United States are done via laparotomy (abdominal incision, not to be confused with laparoscopy). A transverse (Pfannenstiel) incision is made through the abdominal wall, usually above the pubic bone, as close to the upper hair line of the individual's lower pelvis as possible, similar to the incision made for a caesarean section. This technique allows physicians the greatest access to the reproductive structures and is normally done for removal of the entire reproductive complex.[70] The recovery time for an open hysterectomy is 4–6 weeks and sometimes longer due to the need to cut through the abdominal wall. Historically, the biggest problem with this technique was infections, but infection rates are well-controlled and not a major concern in modern medical practice. An open hysterectomy provides the most effective way to explore the abdominal cavity and perform complicated surgeries. Before the refinement of the vaginal and laparoscopic vaginal techniques, it was also the only possibility to achieve subtotal hysterectomy; meanwhile, the vaginal route is the preferable technique in most circumstances.[71][72]
Vaginal hysterectomy
Vaginal hysterectomy is performed entirely through the vaginal canal and has clear advantages over abdominal surgery such as fewer complications, shorter hospital stays and shorter healing time.[73][74] Abdominal hysterectomy, the most common method, is used in cases such as after caesarean delivery, when the indication is cancer, when complications are expected, or surgical exploration is required.
Laparoscopic-assisted vaginal hysterectomy
With the development of laparoscopic techniques in the 1970s and 1980s, the "laparoscopic-assisted vaginal hysterectomy" (LAVH) has gained great popularity among gynecologists because compared with the abdominal procedure it is less invasive and the post-operative recovery is much faster. It also allows better exploration and slightly more complicated surgeries than the vaginal procedure. LAVH begins with laparoscopy and is completed such that the final removal of the uterus (with or without removing the ovaries) is via the vaginal canal. Thus, LAVH is also a total hysterectomy; the cervix is removed with the uterus.[75] If the cervix is removed along with the uterus, the upper portion of the vagina is sutured together and called the vaginal cuff.[76]
Laparoscopic-assisted supracervical hysterectomy
The "laparoscopic-assisted supracervical hysterectomy" (LASH) was later developed to remove the uterus without removing the cervix using a morcellator which cuts the uterus into small pieces that can be removed from the abdominal cavity via the laparoscopic ports.[77]
Total laparoscopic hysterectomy
Total laparoscopic hysterectomy (TLH) was developed in the early 90s by Prabhat K. Ahluwalia in Upstate New York.[78] TLH is performed solely through the laparoscopes in the abdomen, starting at the top of the uterus, typically with a uterine manipulator. The entire uterus is disconnected from its attachments using long thin instruments through the "ports". Then all tissue to be removed is passed through the small abdominal incisions.
Other techniques
Supracervical (subtotal) laparoscopic hysterectomy (LSH) is performed similar to the total laparoscopic surgery but the uterus is amputated between the cervix and fundus.[79]
Dual-port laparoscopy is a form of laparoscopic surgery using two 5 mm midline incisions: the uterus is detached through the two ports and removed through the vagina.[80][81]
"Robotic hysterectomy" is a variant of laparoscopic surgery using special remotely controlled instruments that allow the surgeon finer control as well as three-dimensional magnified vision.[82]
Uterus prior to hysterectomy
Laparoscopical hysterectomy
Cervical stump (white) after removal of the uterine corpus at laparoscopic supracervical hysterectomy
Transvaginal extraction of the uterus in total laparoscopical hysterectomy
End of a laparoscopical hysterectomy
Comparison of techniques
Patient characteristics such as the reason for needing a hysterectomy, uterine size, descent of the uterus, presence of diseased tissues surrounding the uterus, previous surgery in the pelvic region, obesity, history of pregnancy, the possibility of endometriosis, or the need for an oophorectomy, will influence a surgeon's surgical approach when performing a hysterectomy.[83][needs update]
Vaginal hysterectomy is recommended over other variants where possible for women with benign diseases.[71][72][83] Vaginal hysterectomy was shown to be superior to LAVH and some types of laparoscopic surgery causing fewer short- and long-term complications, more favorable effect on sexual experience with shorter recovery times and fewer costs.[84][85][86]
Laparoscopic surgery offers certain advantages when vaginal surgery is not possible but also has the disadvantage of significantly longer time required for the surgery.[83][73]
In one 2004 study conducted in the UK comparing abdominal (laparotomic) and laparoscopic techniques, laparoscopic surgery was found to cause longer operation time and a higher rate of major complications while offering much quicker healing.[87] In another study conducted in 2014, laparoscopy was found to be "a safe alternative to laparotomy" in patients receiving total hysterectomy for endometrial cancer. Researchers concluded the procedure "offers markedly improved perioperative outcomes with a lower reoperation rate and fewer postoperative complications when the standard of care shifts from open surgery to laparoscopy in a university hospital".[88]
The abdominal technique is very often applied in difficult circumstances or when complications are expected. Given these circumstances the complication rate and time required for surgery compares very favorably with other techniques, however time required for healing is much longer.[83]
Hysterectomy by abdominal laparotomy is correlated with much higher incidence of intestinal adhesions than other techniques.[42]
Time required for completion of surgery in the eVAL trial is reported as follows:[87]
abdominal 55.2 minutes average, range 19–155
vaginal 46.6 minutes average, range 14–168
laparoscopic (all variants) 82.5 minutes average, range 10–325 (combined data from both trial arms)
Morcellation has been widely used especially in laparoscopic techniques and sometimes for the vaginal technique, but now appears to be associated with a considerable risk of spreading benign or malignant tumors.[89][90] In April 2014, the FDA issued a memo alerting medical practitioners to the risks of power morcellation.[91]
Robotic assisted surgery is presently used in several countries for hysterectomies. Additional research is required to determine the benefits and risks involved, compared to conventional laparoscopic surgery.[92][92]
A 2014 Cochrane review found that robotic assisted surgery may have a similar complication rate when compared to conventional laparoscopic surgery. In addition, there is evidence to suggest that although the surgery make take longer, robotic assisted surgery may result in shorter hospital stays.[92] More research is necessary to determine if robotic assisted hysterectomies are beneficial for people with cancer.[92]
Previously reported marginal advantages of robotic assisted surgery could not be confirmed; only differences in hospital stay and cost remain statistically significant.[93][94][95] In addition, concerns over widespread misleading marketing claims have been raised.[96]
Summary—Advantages and disadvantages of different hysterectomy techniques
In Canada, the number of hysterectomies between 2008 and 2009 was almost 47,000. The national rate for the same timeline was 338 per 100,000 population, down from 484 per 100,000 in 1997. The reasons for hysterectomies differed depending on whether the woman was living in an urban or rural location. Urban women opted for hysterectomies due to uterine fibroids and rural women had hysterectomies mostly for menstrual disorders.[101]
United States
Hysterectomy is the second most common major surgery among women in the United States (the first is cesarean section). In the 1980s and 1990s, this statistic was the source of concern among some consumer rights groups and puzzlement among the medical community,[102] and brought about informed choice advocacy groups like Hysterectomy Educational Resources and Services (HERS) Foundation, founded by Nora W. Coffey in 1982.
According to the National Center for Health Statistics, of the 617,000 hysterectomies performed in 2004, 73% also involved the surgical removal of the ovaries. There are currently an estimated 22 million women in the United States who have undergone this procedure. Nearly 68 percent were performed for benign conditions such as endometriosis, irregular bleeding and uterine fibroids.[1] Such rates being highest in the industrialized world has led to the controversy that hysterectomies are being largely performed for unwarranted reasons.[103] More recent data suggests that the number of hysterectomies performed has declined in every state in the United States. From 2010 to 2013, there were 12 percent fewer hysterectomies performed, and the types of hysterectomies were more minimally invasive in nature, reflected by a 17 percent increase in laparoscopic procedures.[104]
United Kingdom
In the UK, 1 in 5 women is likely to have a hysterectomy by the age of 60, and ovaries are removed in about 20% of hysterectomies.[105]
Germany
The number of hysterectomies in Germany has been constant for many years. In 2006, 149,456 hysterectomies were performed. Additionally, of these, 126,743 (84.8%) successfully benefitted the patient without incident. Women between the ages of 40 and 49 accounted for 50 percent of hysterectomies, and those between the ages of 50 and 59 accounted for 20 percent.[106] In 2007, the number of hysterectomies decreased to 138,164.[64] In recent years, the technique of laparoscopic or laparoscopically assisted hysterectomies has been raised into the foreground.[107][108]
Denmark
In Denmark, the number of hysterectomies from the 1980s to the 1990s decreased by 38 percent. In 1988, there were 173 such surgeries per 100,000 women, and by 1998 this number had been reduced to 107. The proportion of abdominal supracervical hysterectomies in the same time period grew from 7.5 to 41 percent. A total of 67,096 women underwent hysterectomy during these years.[109]
^Lamvu G (May 2011). "Role of hysterectomy in the treatment of chronic pelvic pain". Obstetrics and Gynecology. 117 (5): 1175–1178. doi:10.1097/AOG.0b013e31821646e1. PMID21508759.
^Petri Nahás EA, Pontes A, Nahas-Neto J, Borges VT, Dias R, Traiman P (February 2005). "Effect of total abdominal hysterectomy on ovarian blood supply in women of reproductive age". Journal of Ultrasound in Medicine. 24 (2): 169–174. doi:10.7863/jum.2005.24.2.169. PMID15661947. S2CID30259666.
^Maas CP, Weijenborg PT, ter Kuile MM (2003). "The effect of hysterectomy on sexual functioning". Annual Review of Sex Research. 14: 83–113. PMID15287159.
^van der Voort DJ, Geusens PP, Dinant GJ (2001). "Risk factors for osteoporosis related to their outcome: fractures". Osteoporosis International. 12 (8): 630–638. doi:10.1007/s001980170062. PMID11580076. S2CID9421669.
^Jassal SK, Barrett-Connor E, Edelstein SL (April 1995). "Low bioavailable testosterone levels predict future height loss in postmenopausal women". Journal of Bone and Mineral Research. 10 (4): 650–654. doi:10.1002/jbmr.5650100419. PMID7610937. S2CID30094806.
^Altman D, Granath F, Cnattingius S, Falconer C (October 2007). "Hysterectomy and risk of stress-urinary-incontinence surgery: nationwide cohort study". Lancet. 370 (9597): 1494–1499. doi:10.1016/S0140-6736(07)61635-3. PMID17964350. S2CID27132159.
^McPherson K, Herbert A, Judge A, Clarke A, Bridgman S, Maresh M, Overton C (July 2005). "Self-reported bladder function five years post-hysterectomy". Journal of Obstetrics and Gynaecology. 25 (5): 469–475. doi:10.1080/01443610500235170. PMID16183583. S2CID38512052.
^Lukanovic A, Drazic K (July 2010). "Risk factors for vaginal prolapse after hysterectomy". International Journal of Gynaecology and Obstetrics. 110 (1): 27–30. doi:10.1016/j.ijgo.2010.01.025. PMID20362288. S2CID24322065.
^Altman D, Falconer C, Cnattingius S, Granath F (May 2008). "Pelvic organ prolapse surgery following hysterectomy on benign indications". American Journal of Obstetrics and Gynecology. 198 (5): 572.e1–572.e6. doi:10.1016/j.ajog.2008.01.012. PMID18355787.
^Gago-Dominguez M, Castelao JE, Yuan JM, Ross RK, Yu MC (November 1999). "Increased risk of renal cell carcinoma subsequent to hysterectomy". Cancer Epidemiology, Biomarkers & Prevention. 8 (11): 999–1003. PMID10566555.
^Quiróz-Guadarrama CD, Martínez-Ordaz JL, Rojano-Rodríguez ME, Beristain-Hernández JL, Moreno-Portillo M (June 2013). "[Vaginal evisceration. Report of a case and a literature review]". Ginecologia y Obstetricia de Mexico. 81 (6): 349–352. PMID23837301.
^Milsom I (June 2007). "The levonorgestrel-releasing intrauterine system as an alternative to hysterectomy in peri-menopausal women". Contraception. 75 (6 Suppl): S152–S154. doi:10.1016/j.contraception.2007.01.003. PMID17531608.
^Lethaby A, Mukhopadhyay A, Naik R (April 2012). Lethaby A (ed.). "Total versus subtotal hysterectomy for benign gynaecological conditions". The Cochrane Database of Systematic Reviews. 4 (4): CD004993. doi:10.1002/14651858.CD004993.pub3. PMID22513925.
^ abThomas B, Magos A (April 2011). "Subtotal hysterectomy and myomectomy - vaginally". Best Practice & Research. Clinical Obstetrics & Gynaecology. 25 (2): 133–152. doi:10.1016/j.bpobgyn.2010.11.003. PMID21185235.
^ abSheth SS, Paghdiwalla KP, Hajari AR (April 2011). "Vaginal route: a gynaecological route for much more than hysterectomy". Best Practice & Research. Clinical Obstetrics & Gynaecology. 25 (2): 115–132. doi:10.1016/j.bpobgyn.2010.12.005. PMID21349773.
^Ahluwalia PK (August 1996). "Total Laparoscopic Hysterectomy". The Journal of the American Association of Gynecologic Laparoscopists. 3 (4, Supplement): S1–S2. doi:10.1016/S1074-3804(96)80129-0. PMID9074073.
^Stovall TG, Summitt RL (August 1996). "Laparoscopic hysterectomy--is there a benefit?". The New England Journal of Medicine. 335 (7): 512–513. doi:10.1056/NEJM199608153350712. PMID8672159.
^Debodinance P (April 2001). "[Hysterectomy for benign lesions in the north of France: epidemiology and postoperative events]". Journal de Gynécologie, Obstétrique et Biologie de la Reproduction. 30 (2): 151–159. PMID11319467.
^Boosz A, Haeberle L, Renner SP, Thiel FC, Mehlhorn G, Beckmann MW, Mueller A (December 2014). "Comparison of reoperation rates, perioperative outcomes in women with endometrial cancer when the standard of care shifts from open surgery to laparoscopy". Archives of Gynecology and Obstetrics. 290 (6): 1215–1220. doi:10.1007/s00404-014-3347-9. PMID25009071. S2CID25074196.
^Ridgeway BM, Buechel M, Nutter B, Falcone T (December 2015). "Minimally Invasive Hysterectomy: An Analysis of Different Techniques". Clinical Obstetrics and Gynecology. 58 (4): 732–739. doi:10.1097/GRF.0000000000000149. PMID26457851. S2CID42747985.
^Schiavone MB, Kuo EC, Naumann RW, Burke WM, Lewin SN, Neugut AI, et al. (September 2012). "The commercialization of robotic surgery: unsubstantiated marketing of gynecologic surgery by hospitals". American Journal of Obstetrics and Gynecology. 207 (3): 174.e1–174.e7. doi:10.1016/j.ajog.2012.06.050. PMID22835493.
^ abLethaby A, Mukhopadhyay A, Naik R (April 2012). "Total versus subtotal hysterectomy for benign gynaecological conditions". The Cochrane Database of Systematic Reviews. 4 (4): CD004993. doi:10.1002/14651858.CD004993.pub3. PMID22513925.
^Mettler L, Ahmed-Ebbiary N, Schollmeyer T (2005). "Laparoscopic hysterectomy: challenges and limitations". Minimally Invasive Therapy & Allied Technologies. 14 (3): 145–159. doi:10.1080/13645700510034010. PMID16754157. S2CID25696299.
^Jäger C, Sauer G, Kreienberg R (2007). "Die laparoskopisch assistierte vaginale Hysterektomie – Sinn oder Unsinn?". Geburtshilfe und Frauenheilkunde. 67 (6): 628–632. doi:10.1055/s-2007-965243. S2CID260157584.
^Gimbel H, Settnes A, Tabor A (March 2001). "Hysterectomy on benign indication in Denmark 1988-1998. A register based trend analysis". Acta Obstetricia et Gynecologica Scandinavica. 80 (3): 267–272. doi:10.1080/j.1600-0412.2001.080003267.x. PMID11207494.
أولاد قاسم تقسيم إداري البلد المغرب الجهة فاس مكناس الإقليم تاونات الدائرة قرية با محمد الجماعة القروية سيدي العابد المشيخة سيدي العابد السكان التعداد السكاني 138 نسمة (إحصاء 2004) • عدد الأسر 23 معلومات أخرى التوقيت ت ع م±00:00 (توقيت قياسي)[1]، وت ع م+01:00 (توقيت صيفي...
Bilateral relationsArgentina-Italy relations Argentina Italy The Argentine Republic and the Italian Republic have had bilateral relations for over a century. Both nations enjoy friendly relations, the importance of which centers on the history of Italian migration to Argentina. Argentines of full or partial Italian ancestry number approximately 30 million, or 62% of the country's total population.[1] Both nations are members of the G20 and the United Nations. History In 1816, Argentin...
لمعانٍ أخرى، طالع أب (توضيح). أبمعلومات عامةصنف فرعي من والدانإنسان ذكر ممثلة بـ ذكر النقيض أمولد درجة القرابة 1 لديه جزء أو أجزاء legal father (en) الأب البيولوجيnon-biological father (en) تعديل - تعديل مصدري - تعديل ويكي بيانات الأبوة مسؤولية بطابع قدسي العلاقات(الخطوط العريضة) أنواع ا�...
William Seltzer RiceWilliam Seltzer Rice, 1906BornJune 23, 1873Manheim, PennsylvaniaDiedAugust 27, 1963 (1963-08-28) (aged 90)Oakland, CaliforniaResting placeManheim, PennsylvaniaNationalityAmericanEducationDrexel University, University of the ArtsAlma materCalifornia College of the ArtsYears active1910–1950sKnown forWoodblock printsMovementArts and Crafts MovementSpouseSusan SteelChildren3 William Seltzer Rice (June 23, 1873 – August 27, 1963) was an American woo...
Peragaan pergerakan buku munculan Buku munculan sering digunakan untuk buku apa pun dengan halaman tiga dimensi. Kartu ucapan tiga dimensi juga termasuk karena menggunakan teknik yang sama.[1] Jenis Diagram geometris prinsip dasar buku munculan: jajaran genjang. Desain dan pembuatan buku-buku dalam seni kadang-kadang disebut teknik kertas. Penggunaan ini tidak boleh disamakan dengan teknik kertas tradisional, rekayasa sistem untuk menghasilkan produk kertas secara besar-besaran. Aspek...
Charles VI saisi de folie non loin du Mans, enluminure du XVe siècle réalisée pour les Chroniques de Jean Froissart. La crise de démence de Charles VI en la forêt du Mans est, le 5 août 1392, la première manifestation de folie du roi de France Charles VI, en lisière de la forêt du Mans. Après la tentative d'assassinat d'Olivier V de Clisson par Pierre de Craon le 13 juin 1392, ce dernier trouve refuge auprès de Jean IV de Bretagne. Charles VI est pressé par ses oncles et les ...
El niño enfermo del pintor chileno Pedro Lira. Con una población estimada para el año 2020 de 20.094.275 habitantes Chile cuenta con una esperanza de vida al nacer de 80 años,[1] en tanto que la tasa de mortalidad infantil fue de 10,5 por mil habitantes, cifras que son la más alta y la más baja respectivamente de América del Sur. Cifras de 1999 de la OMS refieren una tasa de mortalidad general de 510.7 por 100.000 habs. De ellos el primer lugar corresponde a enfermedades del sis...
Indian insurance company This article contains content that is written like an advertisement. Please help improve it by removing promotional content and inappropriate external links, and by adding encyclopedic content written from a neutral point of view. (March 2021) (Learn how and when to remove this template message) Aviva IndiaTypeJoint ventureIndustryFinancial servicesFounded2002HeadquartersGurgaon, HaryanaArea servedIndiaKey peopleMr. Asit Rath(Managing Director & Chief Executive Of...
У этого топонима есть и другие значения, см. Чикаго (значения).Чикагоангл. Chicago River Река в центре города Характеристика Длина 251 км Водоток Исток (Т) (B) Мичиган • Координаты 41°53′12″ с. ш. 87°38′14″ з. д.HGЯO Устье (Т) (B) Дес-Плейнс • ...
Disease outbreak in Singapore This article includes a list of general references, but it lacks sufficient corresponding inline citations. Please help to improve this article by introducing more precise citations. (June 2022) (Learn how and when to remove this template message) 2005 dengue outbreak in SingaporeDiseaseDengue feverVirus strainDengue virusLocationSingaporeDate2005Confirmed cases14,006[1]Severe cases381[1]Deaths27[1]Fatality rate0.19%[1]Government w...
Football clubCS LongueuilFull nameClub Soccer LongueuilFounded1970StadiumCentre Multi-SportPresidentStéphane LamotheLeagueLigue1 Québec2023L1Q-Male, 8thL1Q-Female, 11thWebsiteClub website Home colours Current season Club Soccer Longueuil is a Canadian semi-professional soccer club based in Longueuil, Quebec. Since 2014, the club has competed in Ligue1 Québec.[1] History The club was originally founded in 1970. In 2014, the club joined the Première Ligue de soccer du Québec, a Div...
Provider of audience measurement for U.S. radio Nielsen AudioTypeSubsidiaryIndustryMedia market (research)FoundedWashington, D.C. (1949)HeadquartersColumbia, MarylandArea servedUnited StatesKey peopleSean Creamer, CEOProductsRatings dataRevenueUS$422.31 million(FY 2010)[1]Operating incomeUS$85.11 million (FY 2010)[1]Net incomeUS$53.29 million (FY 2010)[1]Total assetsUS$238.96 million (FY 2010)[1]Total equityUS$126.81 million (FY 2010)[1]OwnerThe Nielsen...
Tourist train in Fukuoka, Japan Heisei Chikuhō Railway 400 type diesel train 401 + 402 Coto Coto Train The Coto Coto Train is a touristic train service in the Fukuoka Prefecture region of Kyushu, southern Japan.[1][2] The service started in 2019.[3] The train is run by the Heisei Chikuhō Railway Company.[1] It was designed by Eiji Mitooka and is based on the concept of “relaxation, delicious food, and fun”.[1] The train is bright red on the outsid...
American actress Vivian RichRich in 1916Born(1893-05-26)May 26, 1893Philadelphia, Pennsylvania, U.S.DiedNovember 17, 1957(1957-11-17) (aged 64)Hollywood, California, U.S.OccupationActressYears active1912–1931SpouseRalph W. Jesson (m. ?–1957) Vivian Rich (May 26, 1893 – November 17, 1957) was an American silent film actress. Career Rich was born in Philadelphia and spent her early years there. Later the family moved to Boston and she completed her education at the Bost...
Organisation générale des consommateursHistoireFondation 1959CadrePays Francemodifier - modifier le code - modifier Wikidata L'Organisation Générale des Consommateurs - OR.GE.CO était une fédération d'associations loi de 1901, créée en 1959[1],[2]. La structure est d'abord commune à trois syndicats, FO, CFTC et CGC pour créer une alternative à l'Union fédérale des consommateurs—Que choisir. Après la loi Royer de 1973, FO se retire de l'ORGECO pour créer l'AFOC et la CF...
AIA Group LimitedHeadquarters at AIA Central in Hong KongNama asli友邦保險控股有限公司JenisPublikKode emitenSEHK: 1299Hang Seng ComponentIndustriAsuransi dan Layanan keuanganDidirikan19 Desember 1919; 104 tahun lalu (1919-12-19)PendiriCornelius Vander StarrKantorpusatAIA CentralCentral, Hong KongWilayah operasiAsia-PasifikTokohkunciLee Yuan Siong (李源祥)(Group Chief Executive dan President)Total asetUS$284 juta (hingga 31 Desember 2019)[1]Situs webaia.com ...
Het Noors voetbalelftal speelde in totaal tien interlands in het jaar 1990, waaronder drie duels in de kwalificatiereeks voor de EK-eindronde (1992) in buurland Zweden. De selectie stond onder leiding van Ingvar Stadheim, die na het duel tegen Hongarije (0-0) opstapte en werd opgevolgd door Egil Olsen. Balans Wedstrijden Doelpunten Punten Gespeeld Winst Gelijk Verlies Voor Tegen Saldo 10 5 2 3 21 13 +8 1.200 Interlands 4 februariMalta Toernooi№ 516 «onderlinge duels» Noorwegen 3 �...
Genus of birds Tesia Russet-capped tesia (Tesia everetti) Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Chordata Class: Aves Order: Passeriformes Family: Cettiidae Genus: TesiaHodgson, 1837 Type species Tesia cyaniventer[1]Hodgson, 1837 The tesias are a genus, Tesia, of Old World warbler. Though once included in the large family Sylviidae, more recent research placed it within a new family, Cettiidae.[2] The four species inhabit undergrowth of montane f...
Paghimo ni bot Lsjbot. 49°46′00″N 9°38′00″E / 49.76667°N 9.63333°E / 49.76667; 9.63333 Weidenloch Lasang Nasod Alemanya Estado pederal Baden-Württemberg Region Gitas-on 191 m (627 ft) Tiganos 49°46′00″N 9°38′00″E / 49.76667°N 9.63333°E / 49.76667; 9.63333 Timezone CET (UTC+1) - summer (DST) CEST (UTC+2) GeoNames 2812965 Lasang ang Weidenloch sa Alemanya.[1] Nahimutang ni sa estado pederal...