University of Washington School of Medicine, Seattle
Research
Molecular basis of Primary immunodeficiency diseases
Awards
Howard Hughes Young Investigator, Honorary Professor of Pediatrics, Chongqing University of Medical Sciences, The Jeffrey Modell Foundation Lifetime Achievement Award
Ochs' research focuses on the molecular basis of primary immunodeficiency diseases with special interest in the genes that have been linked to the Wiskott–Aldrich syndrome, Hyper IgM syndrome, X-linked agammaglobulinemia, IPEX syndrome and autosomal dominante Hyper IgE syndrome. To improve the long-term outcome of these disorders, he has actively participated in clinical trials to develop strategies of immunoglobulin replacement therapies, hematopoietic stem cell transplantation, and gene therapy.
Recently, he focused on the gene Uracil-DNA glycosylase, causing a rare form of autosomal recessive Hyper IgM syndrome, and on STAT3, the gene causing autosomal dominant Hyper IgE syndrome if mutated.
The molecular consequences of heterozygous dominant negative STAT3mutations and their relationship to autosomal-dominant Hyper IgE syndrome
Memberships
He serves on committees for the Immune Deficiency Foundation, the Jeffrey Modell Foundation, the US Immunodeficiency Network (USIDNET), and the International Union of Immunological Societies (IUIS). Ochs is a founding member of the Clinical Immunology Society (CIS) Annual Summer School and is on the editorial board of the Tohoku Journal of Experimental Medicine and the Turkish Journal of Medical Sciences.
2007: Jeffrey Modell Chair of Pediatric Immunity Research
Publications
Books
E. Richard Stiehm, Hans D. Ochs, and Jerry A.Winklestein Immunologic Disorders in Infants and Children, Saunders, 2004, 5th Edition, ISBN978-0-7216-8964-7, ISBN0-7216-8964-7
