Issa grew up in Cardiff, Wales.[3] Her first solo publication was My Body Can House Two Hearts, a pamphlet of poetry published by Burning Eye Books in 2019. The pamphlet was one of three to win Burning Eye's debut pamphlet competition.[4]
During her writing career, Issa has also worked a film-maker and scriptwriter. In 2017, her winning monologue 'With Her Back Straight' was performed at the Bush Theatre as part of the Hijabi Monologues project.[5] In 2020, Issa was the recipient of a Ffilm Cymru/BBC Wales commission, which resulted in her writing and directing the short film The Golden Apple (2022).[6][7] She worked on the Channel 4 comedy series We Are Lady Parts, working alongside the show's creator Nida Manzoor.[8]
Alongside Darren Chetty, Grug Muse and Iestyn Tyne, Issa acted as a contributing editor to the essay anthology Welsh (Plural): Essays on the Future of Wales, published by Repeater Books in 2022.[9] with Issa noting that "connections between one loyalty and another flow as easily for me as one body of water running into another."[10] Issa also co-edited (with Durre Shahwar and Özgür Uyanık) the essay anthology Just So You Know: Essays of Experience, published by Parthian Books in 2020.[11]
In July 2022, Issa was appointed as the National Poet of Wales, succeeding Ifor ap Glyn.[12] The announcement was made on 6 July on BBC Radio 4's Front Row, with presenter Samira Ahmed interviewing Issa following the announcement.[13] Following an extensive selection process, Issa was appointed for a period of three years, with her tenure set to run until 2025. She became the first Muslim poet to hold the title.[14]