Mayagoitia was born in Victoria de Durango, Durango, on 7 January 1923. In 1974, he was nominated by PRI as a candidate for Governor of Durango. Mayagoitia was elected and held the position until 1979 when, less than a year before finishing his term, he was appointed Director of the National Polytechnic Institute. In 1983, he was also named Chief of a main directorate of the National Council of Science and Technology (CONACYT) and in 1988, he was elected as a Senator representing Durango. He has received numerous awards including Commission for Protected areas of Mexico (CONANP) Award for Nature Conservation for his pioneering efforts in the establishment of the first biosphere reserves in Mexico.
Mayagoitia celebrated his 100th birthday in January 2023,[2] and died on 4 October.[3]