DeLisle was born in Fort Ord, California, to truck driver George Van Oosbree and singer Joanna Ruth,[2] and grew up in a Mexican-American household.[5] She has described herself as "a 75% white woman raised by my Mexican grandma".[6] Her parents separated when she was young.[7] She has two brothers.[8][9] DeLisle's mother became a born-againPentecostal when she was eleven and she was later raised by her maternal grandmother, Eva Flores, a vocalist who performed with salsa musicianTito Puente.[2] She credits her father's love of country music as the biggest influence on her musical taste. She attended Chula Vista High School in the same graduating class as Mario Lopez. In her late teens, she started singing old gospel tunes, and entered the world of comedy on the advice of a friend. In her comedy routine, DeLisle imitated voices. Her impressions earned the attention of a casting director and was advised to take up voice acting. At this time, she went back to her musical ambitions but also took classes in voice-overs. She soon began working with talent agent Sandy Schnarr.[10][11]
As of October 2024, DeLisle has voiced over 2,058 roles in 533 titles, as well as dozens of bit parts in 45 titles in which she is credited with "additional voices".
In the Scooby-Doo franchise, DeLisle began voicing Daphne Blake with the direct-to-video film Scooby-Doo and the Cyber Chase, inheriting the role from her friend and teacher Mary Kay Bergman following the latter's suicide.[10] She later said of Bergman, "It was an interesting turn of events to get to play Daphne, but I'm so glad that I have the role, and I was glad that I was able to carry that on for her. She set the bar very high."[10] DeLisle also credited the work for helping her maintain her music career, stating "I think Daphne just saved country music."[12] In 2019, Warner Bros. announced that Amanda Seyfried would be voicing Daphne in the animated film Scoob! instead of DeLisle.[13] Both DeLisle and Matthew Lillard, the current voice of Shaggy Rogers were upset about not being contacted about the decision to recast for their roles for the film.[14][15] Around the time of the film's release, DeLisle said that she did not bear any hard feelings towards Seyfried or her performance in it.[16]
Personal life
Her first marriage was to Christopher DeLisle in 1992. The two later divorced in 1993 after she accidentally confessed to cheating on him.[17] In 2002, she married Murry Hammond of the alt-country band Old 97's; their courtship and wedding were featured in an episode of A Wedding Story.[2][18] She gave birth to their son Jefferson Texas "Tex" Hammond in 2007.[19] They divorced in 2010. She later met Jared Griffin through Twitter, and the two married on June 27, 2012.[20][21] The couple's son Harlan was born in 2014,[22] and a daughter named Mariposa followed in 2016.[23] Their marriage ended the following year.[24]