Keatley was promoted to the Major Leagues by the Kansas City Royals for the first time on September 7, 1981 along with Onix Concepcion, Billy Paschall, Ken Phelps, Jeff Schattinger and Pat Sheridan.[4] Before even appearing in a game, Keatley was in the news when he and teammate Willie Wilson had to restrain teammate George Brett from attacking sportswriter Mike Fish at a hotel in Anaheim.[5] Keatley did not get into his first Major League game until September 27, 1981.[6] He entered as a defensive replacement for Jamie Quirk in the ninth inning of a game at Royals Stadium against the Seattle Mariners and caught a 1-2-3 inning from Dan Quisenberry.[7] His next game would be his final in the majors.[6] On October 5, he again entered as a ninth-inning defensive replacement, this time for John Wathan in a game against the Cleveland Indians at Cleveland Stadium. He caught another 1-2-3 inning from pitcher Atlee Hammaker.[8] As of April 2024[update], no Major League Baseball player has appeared in more games without pitching, hitting or being a baserunner.[9]
Keatley's 1982 season with the Omaha Royals would be his final in professional baseball.[10] After his playing career, he lived with his wife, Karen, and children, Brett and Brandon, in the Lexington, South Carolinaarea while working for more than two decades for Johnson Controls.[2]