Gmina Nowa Brzeźnica is a rural gmina (administrative district) in Pajęczno County, Łódź Voivodeship, in central Poland. Its seat is the village of Nowa Brzeźnica, which lies approximately 15 kilometres (9 mi) south-east of Pajęczno and 81 km (50 mi) south of the regional capital Łódź.
The gmina covers an area of 135.95 square kilometres (52.5 sq mi), and as of 2006 its total population is 5,031.