Glomerulopathy

Glomerulopathy
Specialty	Urology

Glomerulopathy is a disease that impacts the glomeruli in the nephron, either inflammatory or noninflammatory.^[1] Glomerulopathy includes collapsing glomerulopathy, glomerulocystic kidney disease, glomerulomegaly, membranous nephropathy, and tip lesion glomerulopathy.^[2]

Collapsing glomerulopathy (CG) is a clinicopathologic entity that involves hypertrophy and hyperplasia of podocytes and segmentar or global collapse of the glomerulus.^[3]

Glomerulocystic kidney disease is a rare form of renal cyst disease. Cortical microcysts, which are portrayed by cystic dilatation of Bowman's spaces, are its defining feature.^[4]

Glomerulomegaly is defined by unusually large glomeruli.^[5]

Membranous nephropathy (MN) is an uncommon autoimmune condition in which autoantibodies directed primarily against podocyte antigens target the glomerulus, causing electron-dense immune complexes to form, complement activation to occur, and severe proteinuria.^[6]

The glomerular tip lesion (GTL) is a unique histopathologic lesion that appears in idiopathic nephrotic syndrome patients.^[7]

See also

• Glomerulonephritis
• Glomerulonephrosis

References

1. "Monarch Initiative". monarchinitiative.org. Retrieved January 7, 2024.
2. "Glomerulopathy (Concept Id: C0268731)". NCBI. October 31, 2023. Retrieved January 7, 2024.
3. Cutrim, Érico Murilo Monteiro; Neves, Precil Diego Miranda de Meneses; Campos, Marcos Adriano Garcia; Wanderley, Davi Campos; Teixeira-Júnior, Antonio Augusto Lima; Muniz, Monique Pereira Rêgo; Ladchumananandasivam, Francisco Rasiah; Gomes, Orlando Vieira; Vasco, Rafael Fernandes Vanderlei; Brito, Dyego José de Araújo; Lages, Joyce Santos; Salgado-Filho, Natalino; Guedes, Felipe Leite; de Almeida, José Bruno; Magalhães, Marcelo; Araújo, Stanley de Almeida; Silva, Gyl Eanes Barros (March 3, 2022). "Collapsing Glomerulopathy: A Review by the Collapsing Brazilian Consortium". Frontiers in Medicine. 9. Frontiers Media SA. doi:10.3389/fmed.2022.846173. ISSN 2296-858X. PMC 8927620. PMID 35308512.
4. Sahay, M.; Gowrishankar, S. (April 13, 2010). "Glomerulocystic disease". Clinical Kidney Journal. 3 (4). Oxford University Press (OUP): 349–350. doi:10.1093/ndtplus/sfq048. ISSN 2048-8505. PMID 25949428.
5. Hughson, M. D.; Hoy, W. E.; Douglas-Denton, R. N.; Zimanyi, M. A.; Bertram, J. F. (November 29, 2010). "Towards a definition of glomerulomegaly: clinical-pathological and methodological considerations". Nephrology Dialysis Transplantation. 26 (7). Oxford University Press (OUP): 2202–2208. doi:10.1093/ndt/gfq688. ISSN 0931-0509. PMC 3164445. PMID 21115671.
6. Ronco, Pierre; Plaisier, Emmanuelle; Debiec, Hanna (February 5, 2021). "Advances in Membranous Nephropathy". Journal of Clinical Medicine. 10 (4). MDPI AG: 607. doi:10.3390/jcm10040607. ISSN 2077-0383.
7. Stokes, M. Barry; Markowitz, Glen S.; Lin, Julie; Valeri, Anthony M.; D'Agati, Vivette D. (2004). "Glomerular tip lesion: A distinct entity within the minimal change disease/focal segmental glomerulosclerosis spectrum". Kidney International. 65 (5). Elsevier BV: 1690–1702. doi:10.1111/j.1523-1755.2004.00563.x. ISSN 0085-2538. PMID 15086908.

Further reading

• Couser, William G. (May 26, 2017). "Primary Membranous Nephropathy". Clinical Journal of the American Society of Nephrology. 12 (6). Ovid Technologies (Wolters Kluwer Health): 983–997. doi:10.2215/cjn.11761116. ISSN 1555-9041. PMC 5460716. PMID 28550082.
• Ronco, Pierre; Beck, Laurence; Debiec, Hanna; Fervenza, Fernando C.; Hou, Fan Fan; Jha, Vivekanand; Sethi, Sanjeev; Tong, Allison; Vivarelli, Marina; Wetzels, Jack (September 30, 2021). "Membranous nephropathy". Nature Reviews Disease Primers. 7 (1). Springer Science and Business Media LLC. doi:10.1038/s41572-021-00303-z. ISSN 2056-676X. PMID 34593809.

External links