On May 25, 1929, the Detroit Tigers defeated the Chicago White Sox 6–5 in 21 innings. Uhle, who was the winning pitcher, pitched twenty innings to earn his eighth win of the season with no losses. The losing pitcher, Ted Lyons, pitched all 21 innings for Chicago.
Babe Ruth himself credited George with being the toughest pitcher he ever faced, although Ruth batted .336 against Uhle. Out of 714 career home runs, he got only four off Uhle. Uhle had the second most strikeouts of Ruth by a pitcher, with 25. Only Lefty Grove had more, with 27.
Uhle's son, George, Jr., played minor league baseball in the Boston Braves' organization for a few years.[1][2]
Uhle was buried at Lakewood Park Cemetery in Rocky River, Ohio.