Born to a Jewish family,[2] Lederer began his career when he joined a touring opera company at age 13, as a soprano singer. When he reached the age of 17, he collaborated with the producer Thomas Canary and leased the Casino Theatre, in New York City. In 1897, at age 25, he produced the musical The Belle of New York, which became one of the first American musicals to enjoy enduring success in England, where it ran for over two years.
He was married on October 19, 1889, to Ida Florine Newcombe, with whom he had a son, George W. Lederer Jr. (1891–1924), who became a theatre manager and press agent before dying aged 33.[3][4] He was divorced from Newcombe and married to Adele Rice on the same day in November, 1894.[4] Their son Maitland Rice Lederer became a motion picture executive.[5] He and Rice were divorced in 1906, and he married actress Reine Davies in January, 1907.[6] Their daughter Josephine Rose "Pepi" Lederer became a film actress, and son Charles Lederer became a screenwriter.[7] He later married Jessie Lewis, with whom he had two daughters, Glory and Geraldine.[8]