GINS (protein complex)

GINS is a protein complex essential to the DNA replication process in the cells of eukaryotes. The complex participates in the initiation and elongation stages of replication.

The name GINS is an acronym created from the first letters of the Japanese numbers 5-1-2-3 (go-ichi-ni-san) in a reference to the 4 protein subunits of the complex: Sld5, Psf1, Psf2, and Psf3.^[1]

A similar complex has been identified in Archaea.^[2]

See also

• Eukaryotic DNA replication#GINS Explains role of GINS during DNA replication in eukaryotic cells.

References

1. MacNeill, Stuart (Jan 2010). "Structure and function of the GINS complex, a key component of the eukaryotic replisome". Biochemical Journal. 425 (3): 489–500. doi:10.1042/BJ20091531.
2. Labib, Karim; Gambus, Agnieszka (June 2007). "A key role for the GINS complex at DNA replication forks". Trends in Cell Biology. 17 (6): 271–278. doi:10.1016/j.tcb.2007.04.002. PMID 17467990.