Frizzled-8

FZD8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IJY, 4F0A
Identifiers
Aliases	FZD8, FZ-8, hFZ8, frizzled class receptor 8
External IDs	OMIM: 606146 MGI: 108460 HomoloGene: 40606 GeneCards: FZD8
Gene location (Human)
Chr.	Chromosome 10 (human)
End	35,642,296 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	9,218,136 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; retinal pigment epithelium; ; spongy bone; ; lactiferous duct; ; pancreatic epithelial cell; ; pancreatic ductal cell; ; spinal ganglia; ; trigeminal ganglion; ; pericardium; ; right ventricle;
	Top expressed in
	hypoblast; ; calvaria; ; retinal pigment epithelium; ; left lobe of liver; ; ankle; ; ciliary body; ; molar; ; trigeminal ganglion; ; atrium; ; respiratory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane signaling receptor activity; signaling receptor binding; ubiquitin protein ligase binding; protein binding; signal transducer activity; PDZ domain binding; G protein-coupled receptor activity; Wnt-protein binding; Wnt-activated receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; Golgi apparatus; Wnt-Frizzled-LRP5/6 complex;
Biological process	positive regulation of protein phosphorylation; positive regulation of JUN kinase activity; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; angiogenesis; positive regulation of transcription by RNA polymerase II; multicellular organism development; negative regulation of transcription by RNA polymerase II; neuron differentiation; signal transduction; Wnt signaling pathway; T cell differentiation in thymus; non-canonical Wnt signaling pathway; canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8325
	14370
	ENSG00000177283
	ENSMUSG00000036904
	Q9H461
	Q61091
	NM_031866
	NM_008058
	NP_114072
	NP_032084
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.^[5]^[6]

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177283 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036904 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol. 18 (5): 991–6. doi:10.3892/ijo.18.5.991. PMID 11295046.
^ ^a ^b "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)".

External links

"Frizzled Receptors: FZD₈". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-09-03. Retrieved 2008-12-04.
Overview of all the structural information available in the PDB for UniProt: Q9H461 (Human Frizzled-8 (FZD8)) at the PDBe-KB.