Guevara-Escudero was born and raised in Quezon City.[1] She graduated from University of the Philippines (UP) in 1964 with a degree in home economics, major in food and nutrition.[2] She also obtained her masters and doctorate degree in education from the same university in 1999 and 2004, respectively.[3] She was a UP College of Home Economics faculty member and was active in various organizations including becoming president of the UP Home Economics Alumni Association and treasurer of the UP Alumni Association.[4] From 1987 to 1996, she was a professor at OB Montessori Professional High School and from 1996 to at least 2012, professor at OB Montessori College.[1][5] In 2012, she was appointed by then-President Benigno Aquino III to the UP Board of Regents.[2][4]
Guevara-Escudero was married to Salvador Escudero and has three children. Following her husband's death in August 2012, she ran for his vacant seat in the 2013 elections and won, garnering 55,425 or 50% of the total votes cast. She ran unopposed in the succeeding 2016 election and won again in 2019 garnering 118,436 votes. In all of these elections, she ran under the Nationalist People's Coalition party.