Emeke Egbule attended North Shore Senior High School. He played both football and basketball for his school. He was named to the 2013 district 21-5A all-district first-team as a tight end.
On August 31, 2021, Egbule was waived by the Chargers and re-signed to the practice squad the next day.[5][6] He signed a reserve/future contract with the Chargers on January 11, 2022.[7]
On August 30, 2022, Egbule was waived by the Chargers.[8]
Pittsburgh Steelers
On December 7, 2022, Egbule was signed to the Pittsburgh Steelers practice squad.[9] He signed a reserve/future contract on January 10, 2023.[10] He was released on May 22, 2023.[11]
On November 16, 2022, Egbule was selected by the St. Louis Battlehawks of the XFL in the 2023 XFL Draft, but did not play after signing with the Steelers. He signed a letter of intent with the Battlehawks on December 6, 2023.[14] He was waived on March 22, 2024.[15]
Edmonton Elks (second stint)
On March 26, 2024, Egbule returned to the Elks.[16] He was released on May 15.[17]