Smith made her stage debut in the 2006 play The Pocket Orchestra at the Trafalgar Studios in London. She returned to the same venue in 2008 to play Helen, the love interest of Neil LaBute's Fat Pig.
In 2007, she was in Channel 4'sCape Wrath, in which she played the regular role of Jezebel Ogilvie, the daughter of Brenda Ogilvie (Melanie Hill). She also starred in ITV's series Sold as Phoebe.
In 2015 she played the role of Mia in the Channel 4 series Babylon. After a successful Kickstarter campaign, in 2016 Smith's short film Mdudu Boy premiered, featuring Kenyan footballer Victor Wanyama.[1]