During her freshman season, she set an American record in the 200-yard individual medley.[3] At the 2016 NCAA Championships, she won the 200-yard and 400-yard individual medleys, and placed second behind Kelsi Worrell in the 200-yard butterfly.[4]
During the first day of the 2017 NCAA Championships, Eastin, along with her teammates Simone Manuel, Lia Neal, and Katie Ledecky, set a record of 6:45.91 in the 800-yard freestyle relay. She lost the 200-yard individual medley to Kathleen Baker, but successfully defended her 400-yard individual medley title by breaking teammate Katie Ledecky's American record. She also added a win in the 200-yard butterfly.
In the 2018 NCAA Championships, Eastin set new NCAA and American records in the 200-yard individual medley with a time of 1:50.67, and she shattered Katie Ledecky's American record in the 400-yard individual medley by almost two seconds, with a time of 3:54.60. She also won the 200-yard butterfly, and she was a member of the winning relay teams in the 400-yard and 800-yard relays. Eastin was named Swimmer of the Meet.[5]
In the 2019 NCAA Championships, Eastin won the 400-yard individual medley, and in so doing became the only woman to win four consecutive national titles in the event. She finished second in the 200-yard individual medley and in the 200-yard butterfly. She and her teammates Grace Zhao, Amalie Fackenthal, and Anya Goeders won the 200-yard medley relay. She and her teammates Katie Drabot, Taylor Ruck, and Brooke Forde took silver in the 800-yard freestyle relay.[6]
During the 2017 Phillips 66 National Championships, Eastin grabbed second place behind Leah Smith in the 400 metre individual medley, technically qualifying her for the 2017 World Aquatics Championships in Budapest, but was disqualified for the Lochte rule.
She was named a team captain for the 2017 World University Games in Taipei.
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