Edithvale station gets it name from Edithvale Road, itself named after a local farm, Edithvale Farm, which was established in the 1850s and owned by John and Edith Greves.[5][6]
In its early years, a siding existed at the on the down side before Platform 2.[7]
In 1978, boom barriers replaced interlocked gates at the former Edithvale Road level crossing, which was located at the down end of the station.[8] In 1981, the former ground level station buildings were provided.[9]
On 28 July 2019, the Level Crossing Removal Project announced that the Edithvale Road level crossing had been fast-tracked for grade separation by 2022.[10] Construction started in 2020, with the former ground-level station closing on 25 July 2021 for demolition.[11] As part of the project, the line was lowered into a trench, and the station rebuilt, along with Chelsea and Bonbeach stations.[12] On 22 November of that year, the new below-ground station opened to passengers.[13][14]