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The East Village/Lower East Side Historic District in Lower Manhattan, New York City was created by the New York City Landmarks Preservation Commission on October 9, 2012.^[1] It encompasses 330 buildings, mostly in the East Village neighborhood, primarily along Second Avenue between East 2nd and 6th Streets, and along the side streets. Some of the buildings are located in a second area between First Avenue and Avenue A along East 6th and 7th Streets. The district is based on the one which had been proposed by the Greenwich Village Society for Historic Preservation, with only minor changes, and is the result of a two-year effort to protect the area.^[2]^[3]

Significant buildings which are located within the district include Congregation Adas Yisroel Anshe Mezeritz Synagogue at 415 East 6th Street, the OCA Cathedral of the Protection of the Holy Virgin at 59 East 2nd Street, the Community Synagogue at 323 East 6th Street which was originally the Evangelical Lutheran Church of St. Matthew, from which parish many of the victims of the General Slocum disaster came, the building housing the Pyramid Club at 101 Avenue A,^[3] and the Middle Collegiate Church at 112 Second Avenue. In addition the district features many row houses and tenements in the Greek Revival style, and numerous buildings constructed for the German immigrants who dominated the neighborhood in the late 19th and early 20th centuries.^[2] The district also includes the theatres on East 4th Street between Second Avenue and the Bowery, which the city has named a cultural district,^[2] as well as several remnants of the theatres on Second Avenue when Yiddish theatre thrived there and it was called the "Jewish Rialto".