Lesko was considered the top pitcher available in the 2022 Major League Baseball draft before the season started.[6] He was committed to Vanderbilt University to play college baseball.[7] His season ended when he tore the UCL in his pitching elbow, an injury that required Tommy John surgery, which he underwent on April 26 and was expected to sideline him until 2024. Regardless, the San Diego Padres selected Lesko in the first round, with the 15th overall selection, of the draft.[8] Lesko signed with the Padres for a $3.9 million signing bonus, forgoing his commitment to Vanderbilt.[9]
Lesko was able to return to action in 2023, splitting the year between the rookie–level Arizona Complex League Padres, Single–A Lake Elsinore Storm, and High–A Fort Wayne TinCaps. In 12 total starts, he accumulated a 1–5 record and 5.45 ERA with 52 strikeouts across 33 innings pitched. [10]