As a freshman in 2007, McDaniel was a first-team All-ACC freshman selection by Sporting News after recording 33 tackles and two interceptions. As a sophomore in 2008 the Tigers moved him to linebacker. He finished the season with 77 tackles and an interception.
In June 2008, McDaniel was arrested for assault and battery of a high and aggravated nature after an argument with his girlfriend. McDaniel reportedly choked his girlfriend, punched her in the head and chest, and pushed her down a flight of stairs, causing her to seek medical attention for "serious bodily injury".[1][2]
In 2009, McDaniel was moved back to safety, where he recorded eight interceptions, with one returned for a touchdown. After a bowl victory over Kentucky, McDaniel decided to return to Clemson for the 2010 season. His eight interceptions tied a Clemson school record.
In 2010, McDaniel finished with 4 interceptions and 75 total tackles, including 12 in the Meineke Car Care Bowl. Despite his strong collegiate career and physical talent he was not selected in the NFL Draft.