Niose joined the American Humanist Association board of directors in 2005. He served two terms as president of the AHA, before becoming president of the Secular Coalition. In January 2014 he left the presidency of the Secular Coalition for America to become legal director of the American Humanist Association.[5]
Upon joining the AHA board in 2005, Niose helped develop and launch a national advertising campaign promoting humanism in 2005, one of the first national ad campaigns by a secular group in America.[6][7] The campaign included a series of full-page ads in several national magazines.[8] As AHA president Niose oversaw additional advertising campaigns which have included national television, radio, billboards, and public transit.[9] These efforts have since been replicated by other secular groups.[10] In late 2011 the AHA launched a $200,000 holiday billboard campaign, placing advertisements in 7 different cities, which included a billboard reading "Yes, Virginia, there is no god.".[11]
In 2007 Niose initiated a contest sponsored by the Secular Coalition for America that resulted in Rep. Pete Stark (D-CA) becoming the first member of Congress to openly identify as an atheist.[12] As AHA president Niose urged President Obama to decline the honorary presidency of the Boy Scouts until their policy to exclude atheists is changed. .[13]
Niose developed a legal strategy arguing the concept of equal rights and nondiscrimination rather than the First Amendment's Establishment Clause in cases protecting religious minorities.[14] In 2014 the AHA brought suit against a New Jersey school district, taking the approach that the phrase "under God" in the Pledge of Allegiance was discriminatory against atheists.[15] In February 2015 a New Jersey Superior Court Judge dismissed the suit ruling that "...the Pledge of Allegiance does not violate the rights of those who don't believe in God and does not have to be removed from the patriotic message."[16] This followed a similar ruling of the Massachusetts Supreme Judicial Court in May 2014[16]
Niose is the author of Nonbeliever Nation: The Rise of Secular Americans, released in 2012 by Palgrave Macmillan.[33] A second book, Fighting Back the Right: Reclaiming America from the Attack on Reason, was released in 2014.[34]