This film is a sequel to Daughter that was released a year earlier. The film series Daughter has a theme about the issues of teenagers in Thai society.
Daughter 2 contains a story about a Thai-Westerner high school student, a teenage girl who accidentally gets infected with HIV. It is the first performance of Marisa Anita, a Thai-Dutch actress.
The film has Arunroj Liamthong a real reporter playing the role of Pasinee Srikamroong a female reporter who reports on the issue leading to social awareness.