Chromosome 6

Chromosome 6
Human chromosome 6 pair after G-banding.
One is from mother, one is from father.
Chromosome 6 pair
in human male karyogram.
Features
Length (bp)172,126,628 bp
(CHM13)
No. of genes996 (CCDS)[1]
TypeAutosome
Centromere positionSubmetacentric[2]
(59.8 Mbp[3])
Complete gene lists
CCDSGene list
HGNCGene list
UniProtGene list
NCBIGene list
External map viewers
EnsemblChromosome 6
EntrezChromosome 6
NCBIChromosome 6
UCSCChromosome 6
Full DNA sequences
RefSeqNC_000006 (FASTA)
GenBankCM000668 (FASTA)

Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans nearly 171 million base pairs (the building material of DNA) and represents between 5.5 and 6% of the total DNA in cells. It contains the major histocompatibility complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation.

The evolution of human centromere 6

The centromere of chromosome 6 illustrates an interesting example of centromere evolution. It was known[further explanation needed] that in a Catarrhini ancestor the chromosome 6 centromere was situated near position 26 Mb of the modern human chromosome. In Macaca mulatta, this old centromere went defunct and repositioned to a different chromosomal location[relevant?]. In the case of humans, the old centromere went defunct and a more recent form emerged near the modern position of human cen6 (size of 60 Mb). Such cases are known as Evolutionary New Centromeres (ENC). This assembly phenomenon of the human chromosome 6 gives researchers an opportunity to investigate the origin of the ENC on chromosome 6. [4]

Genes

The human leukocyte antigen lies on chromosome 6, with the exception of the gene for β2-microglobulin (which is located on chromosome 15), and encodes cell-surface antigen-presenting proteins among other functions.

Number of genes

In 2003, the entirety of chromosome 6 was manually annotated for proteins, resulting in the identification of 1,557 genes, and 633 pseudogenes.[5]

The following are some of the newer gene count estimates. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[6]

Estimated by Protein-coding genes Non-coding RNA genes Pseudogenes Source Release date
CCDS 996 — — [1] 2016-09-08
HGNC 1,007 422 736 [7] 2017-05-12
Ensembl 1,038 985 800 [8] 2017-03-29
UniProt 1,111 — — [9] 2018-02-28
NCBI 1,053 1,188 911 [10][11][12] 2017-05-19

Gene list

See also: Category:Genes on human chromosome 6

The following is a partial list of genes on human chromosome 6. For complete list, see the link in the infobox on the right.

p-arm

The following are some of the genes located on p-arm (short arm) of human chromosome 6:

  • ADTRP: encoding protein Androgen-dependent TFPI-regulating protein
  • APOM: encoding protein Apolipoprotein M (6p21.33)
  • ARMC12: encoding protein Armadillo repeat containing 12
  • ATXN1: encoding protein Ataxin 1 (6p16.3-p16.76)
  • TSBP1: encoding protein TSBP1 (6p21.32)
  • C6orf62: chromosome 6 open reading frame 62 (6p22.3)
  • C6orf89: chromosome 6 open reading frame 89 (6p21.2)
  • CDKAL1: CDK5 regulatory subunit associated protein 1 like 1 (6p22.3)
  • COL11A2: collagen, type XI, alpha 2(6p21.3)
  • CRIP3: encoding protein Cysteine rich protein 3
  • CYP21A2: cytochrome P450, family 21, subfamily A, polypeptide 2 (6p21.33)
  • DHX16: DEAH-box helicase 16 (6p21.33)
  • DOM3Z: Decapping exoribonuclease (6p21.33)
  • DSP: Desmoplakin gene linked to cardiomyopathy (6p24.3)
  • ELOVL5: ELOVL fatty acid elongase 5 (6p12.1)
  • FBXO9: F-box protein 9 (6p12.1)
  • FOXP4-AS1: encoding protein FOXP4 antisense RNA 1
  • FTH1P5: encoding protein Ferritin, heavy polypeptide 1 pseudogene 5
  • G6B: Protein G6b (6p21.33)
  • GCNT2: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (6p24.3)
  • GGNBP1: encoding protein Gametogenetin binding protein 1 (pseudogene)
  • GMDS: GDP-mannose 4,6-dehydratase (6p25.3)
  • GTPBP2: encoding protein Gtp binding protein 2
  • HCG4P11: HLA complex group 4 pseudogene 11
  • HFE: hemochromatosis (6p22.2)
  • HIST1H2AH: histone cluster 1 H2A family member h (6p22.1)
  • HLA-A, HLA-B, HLA-C: major histocompatibility complex (MHC), class I, A, B, and C loci. (6p21.3)
  • HLA-DQA1 and HLA-DQB1 form HLA-DQ heterodimer MHC class II, DQ: Celiac1, IDDM (6p21.3)
  • HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 forms HLA-DR, heterodimer MHC class II, DR (6p21.3) Mold / Biotoxin Susceptibility
  • HLA-DPA1 and HLA-DPB1 forms HLA-DP, MHC class II, DP (6p21.3)
  • HLA-Cw*06:02: gene variation related to psoriasis (6p21.3)
  • KAAG1: encoding protein Kidney associated antigen 1
  • LOC100533655: encoding protein Aryl hydrocarbon receptor pseudogene
  • LST1: leukocyte specific transcript 1 (6p21.33)
  • LY6G6E encoding protein Lymphocyte antigen 6 complex, locus G6E (pseudogene) (6p21.33)
  • MIR4640: microRNA 4640 (6p21.33)
  • MLIP: muscular LMNA interaction protein (6p12.1)
  • MRPS18B: mitochondrial ribosomal protein S18B (6p21.33)
  • MUT: methylmalonyl Coenzyme A mutase (6p12.3)
  • NHLRC1: NHL repeat containing E3 ubiquitin protein ligase 1 (6p22.3)
  • NOL7: nucleolar protein 7 (6p23)
  • NQO2: N-ribosyldihydronicotinamide:quinone reductase 2 (6p25.2)
  • NRSN1: neurensin 1 (6p22.3)
  • NUDT3: nudix hydrolase 3 (6p21.31)
  • PFDN6: prefoldin subunit 6 (6p21.32)
  • PHACTR1: phosphatase and actin regulator 1 (6p24.1)
  • PKHD1: polycystic kidney and hepatic disease 1 (autosomal recessive) (6p21.2-p12)
  • PRICKLE4: prickle planar cell polarity protein 4 (6p21.1)
  • PRSS16: protease, serine 16 (6p22.1)
  • PSMB8-AS1: PSMB8 antisense RNA 1 (head to head) (6p21.32)
  • RAB44: encoding protein Rab44, member ras oncogene family
  • RIPOR2: RHO family interacting cell polarization regulator 2 (6p22.3)
  • RPL10A: encoding protein 60S ribosomal protein L10a (6p21.31)
  • SKIV2L: Ski2 like RNA helicase (6p21.33)
  • SSR1: signal sequence receptor subunit 1 (6p24.3)
  • TCF19: transcription factor 19 (6p21.33)
  • TCP11: t-complex 11 (6p21.31)
  • TJAP1: tight junction associated protein 1 (6p21.1)
  • TP53COR1 encoding protein Tumor protein p53 pathway corepressor 1 (non-protein coding)
  • TMEM151B: encoding protein Transmembrane protein 151B
  • TNXB: tenascin XB (6p21.3)
  • TRAM2: translocation associated membrane protein 2 (6p12.2)
  • TRIM38: encoding protein Tripartite motif containing 38
  • TTBK1: encoding protein Tau tubulin kinase 1
  • UBR2: ubiquitin protein ligase E3 component n-recognin 2 (6p21.2)
  • UNC5CL: encoding protein Unc-5 homolog C (C. elegans)-like
  • USP8P1: encoding protein Ubiquitin specific peptidase 8 pseudogene 1
  • VEGF: vascular endothelial growth factor A (angiogenic growth factor) (6p21.1)
  • VPS52: GARP complex subunit
  • VWA7: encoding protein Von willebrand factor a domain containing 7
  • ZKSCAN4: encoding protein zinc finger with KRAB and SCAN domains 4
  • ZNF76: zinc finger protein 76 (6p21.31)
  • ZNF193: zinc finger protein 193 (6p22.1)
  • ZNRD1: zinc ribbon domain containing 1 (6p22.1)

q-arm

The following are some of the genes located on q-arm (long arm) of human chromosome 6:

  • AIM1: encoding protein Absent in melanoma 1 protein (6q21)
  • AIG1: encoding protein Androgen-induced protein 1 (6q24.2)
  • AKIRIN2: akirin 2 (6q15)
  • ARG1: arginase 1 (6q23.2)
  • BCKDHB: branched-chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) (6q14.1)
  • BMIQ3: body mass index QTL 3
  • TMEM242 encoding transmembrane protein TMEM242
  • C6orf203: encoding protein Chromosome 6 open reading frame 203
  • C6orf58: chromosome 6 open reading frame 58 (6q22.33)
  • CFAP206: encoding protein Cilia And Flagella Associated Protein 206
  • CMD1F: cardiomyopathy, dilated 1F
  • CMD1K: cardiomyopathy, dilated 1K
  • CNR1: cannabinoid 1 receptor (6q14-q15)[13]
  • DACT2: encoding protein Dishevelled binding antagonist of beta catenin 2
  • DFNB38: deafness, autosomal recessive 38
  • DYX4: dyslexia susceptibility 4
  • ECT2L: encoding protein Epithelial cell transforming sequence 2 oncogene-like
  • ESR1: Estrogen receptor 1 (6q25)
  • EYA4: eyes absent homolog 4 (Drosophila)(6q23.2)
  • FBXL4: F-box and leucine rich repeat protein 4 (6q16.1-q16.2)
  • FEB5: febrile convulsions 5
  • HACE1: HECT domain and Ankyrin repeat containing, E3 ubiquitin protein ligase 1 (6q21)
  • HEBP2: heme binding protein 2 (6q24.1)
  • IDDM8: insulin dependent diabetes mellitus 8
  • IDDM15: insulin dependent diabetes mellitus 15
  • IFNGR: interferon-γ receptor gene (6q23-q24)
  • IGF2R: insulin-like growth factor 2 receptor (6q25.3)
  • IMPG1: interphotoreceptor matrix proteoglylcan 1 (6q14.1)
  • KIAA0408
  • LGSN: encoding protein lengsin
  • LIN28B: lin-28 homolog B (6q16.3-q21)
  • MAN1A1: mannosidase alpha class 1A member 1 (6q22.31)
  • MB21D1: encoding protein Mab-21 domain containing 1
  • MCDR1: macular dystrophy, retinal, 1
  • MDN1: midasin AAA ATPase 1 (6q15)
  • MOXD1: monooxygenase DBH like 1 (6q23.2)
  • MTO1: mitochondrial tRNA translation optimization 1 (6q13)
  • MRT18: mental retardation, non-syndromic, autosomal recessive
  • MRT28: mental retardation, non-syndromic, autosomal recessive
  • MTRF1L: mitochondrial translational release factor 1 like (6q25.2)
  • MYO6: myosin VI (6q14.1)
  • NHEG1: encoding protein Neuroblastoma highly expressed 1
  • OA3: ocular albinism 3
  • OPRM1: μ-opioid receptors (6q24-q25)
  • OTSC7: otosclerosis 7
  • PLG: plasminogen (6q26)
  • PBCRA1
  • PARK2: Parkinson disease (autosomal recessive, juvenile) 2, parkin (6q26)
  • PCMT1: protein-L-isoaspartate (D-aspartate) O-methyltransferase (6q25.1)
  • PERP: p53 apoptosis effector related to PMP-22 (6q23.3)
  • PKIB: cAMP-dependent protein kinase inhibitor beta (6p22.31)
  • PLAGL1: (6q24.2)
  • QRSL1: encoding protein Glutaminyl-trna synthase (glutamine-hydrolyzing)-like 1
  • RCD1: retinal cone dystrophy 1
  • RFPL4B: Ret finger protein like 4B
  • RP63: retinitis pigmentosa 63
  • SASH1: SAM and SH3 domain containing 1 (6q24.3-q25.1)
  • SCZD5: schizophrenia disorder 5
  • SEN6: senescence (cellular)-related 6
  • SENP6: SUMO1/sentrin specific peptidase 6 (6q14.1)
  • SERAC1: serine active site containing 1 (6q25.3)
  • SERINC1: serine incorporator 1 (6q22.31)
  • SF3B5: splicing factor 3b subunit 5 (6q24.2)
  • SMAP1: small ArfGAP 1 (6q13)
  • SOBP: sine oculis binding protein homolog (6q21)
  • SPG25: spastic paraplegia 25
  • SYNJ2: synaptojanin 2 (6q25.3)
  • T: T brachyury transcription factor (more commonly known as the T gene) linked to Hepatocellular carcinoma and Chordoma (6q27)[14]
  • TAAR1: trace amine associated receptor 1 (6q23.1)
  • TAAR2: trace amine associated receptor 2 (6q24)
  • TMEM200A: encoding protein Transmembrane protein 200A
  • TSPYL1: TSPY like 1 (6q22.1)
  • UNC93A: encoding protein Unc-93 homolog A (C. elegans)
  • VNN1: vanin 1 (6q23.2)
  • VNN2: vanin 2 (6q23.2)
  • VTA1: Vesicle trafficking 1 (6q24.1-2)
  • ZC2HC1: encoding protein Zinc finger C2HC-type containing 1B
  • ZDHHC14: encoding protein Zinc finger, DHHC-type containing 14

Diseases and disorders

The following diseases are some of those related to genes on chromosome 6:

Cytogenetic band

G-banding ideograms of human chromosome 6
G-banding ideogram of human chromosome 6 in resolution 850 bphs. Band length in this diagram is proportional to base-pair length. This type of ideogram is generally used in genome browsers (e.g. Ensembl, UCSC Genome Browser).
G-banding patterns of human chromosome 6 in three different resolutions (400,[15] 550[16] and 850[3]). Band length in this diagram is based on the ideograms from ISCN (2013).[17] This type of ideogram represents actual relative band length observed under a microscope at the different moments during the mitotic process.[18]
G-bands of human chromosome 6 in resolution 850 bphs[19]
Chr. Arm[20] Band[21] ISCN
start[22] 		ISCN
stop[22] 		Basepair
start 		Basepair
stop 		Stain[23] Density
6 p 25.3 0 118 1 2,300,000 gneg
6 p 25.2 118 207 2,300,001 4,200,000 gpos 25
6 p 25.1 207 355 4,200,001 7,100,000 gneg
6 p 24.3 355 548 7,100,001 10,600,000 gpos 50
6 p 24.2 548 592 10,600,001 11,600,000 gneg
6 p 24.1 592 740 11,600,001 13,400,000 gpos 25
6 p 23 740 844 13,400,001 15,200,000 gneg
6 p 22.3 844 1185 15,200,001 25,200,000 gpos 75
6 p 22.2 1185 1348 25,200,001 27,100,000 gneg
6 p 22.1 1348 1585 27,100,001 30,500,000 gpos 50
6 p 21.33 1585 1718 30,500,001 32,100,000 gneg
6 p 21.32 1718 1836 32,100,001 33,500,000 gpos 25
6 p 21.31 1836 2162 33,500,001 36,600,000 gneg
6 p 21.2 2162 2310 36,600,001 40,500,000 gpos 25
6 p 21.1 2310 2755 40,500,001 46,200,000 gneg
6 p 12.3 2755 3080 46,200,001 51,800,000 gpos 100
6 p 12.2 3080 3140 51,800,001 53,000,000 gneg
6 p 12.1 3140 3377 5,300,0001 57,200,000 gpos 100
6 p 11.2 3377 3421 57,200,001 58,500,000 gneg
6 p 11.1 3421 3554 58,500,001 59,800,000 acen
6 q 11.1 3554 3658 59,800,001 62,600,000 acen
6 q 11.2 3658 3732 62,600,001 62,700,000 gneg
6 q 12 3732 4147 62,700,001 69,200,000 gpos 100
6 q 13 4147 4324 69,200,001 75,200,000 gneg
6 q 14.1 4324 4621 75,200,001 83,200,000 gpos 50
6 q 14.2 4621 4709 83,200,001 84,200,000 gneg
6 q 14.3 4709 4917 84,200,001 87,300,000 gpos 50
6 q 15 4917 5228 87,300,001 92,500,000 gneg
6 q 16.1 5228 5613 92,500,001 98,900,000 gpos 100
6 q 16.2 5613 5687 98,900,001 100,000,000 gneg
6 q 16.3 5687 5983 10,000,0001 105,000,000 gpos 100
6 q 21 5983 6531 10,500,0001 114,200,000 gneg
6 q 22.1 6531 6753 114,200,001 117,900,000 gpos 75
6 q 22.2 6753 6872 117,900,001 118,100,000 gneg
6 q 22.31 6872 7168 118,100,001 125,800,000 gpos 100
6 q 22.32 7168 7345 125,800,001 126,800,000 gneg
6 q 22.33 7345 7642 126,800,001 130,000,000 gpos 75
6 q 23.1 7642 7923 13,000,0001 130,900,000 gneg
6 q 23.2 7923 8145 130,900,001 134,700,000 gpos 50
6 q 23.3 8145 8352 134,700,001 138,300,000 gneg
6 q 24.1 8352 8560 138,300,001 142,200,000 gpos 75
6 q 24.2 8560 8708 142,200,001 145,100,000 gneg
6 q 24.3 8708 8886 145,100,001 148,500,000 gpos 75
6 q 25.1 8886 9078 148,500,001 152,100,000 gneg
6 q 25.2 9078 9241 152,100,001 155,200,000 gpos 50
6 q 25.3 9241 9596 155,200,001 160,600,000 gneg
6 q 26 9596 9774 160,600,001 164,100,000 gpos 50
6 q 27 9774 10100 164,100,001 170,805,979 gneg

References

  1. ^ a b "Search results - 6[CHR] AND "Homo sapiens"[Organism] AND ("has ccds"[Properties] AND alive[prop]) - Gene". NCBI. CCDS Release 20 for Homo sapiens. 2016-09-08. Retrieved 2017-05-28.
  2. ^ Tom Strachan; Andrew Read (2 April 2010). Human Molecular Genetics. Garland Science. p. 45. ISBN 978-1-136-84407-2.
  3. ^ a b Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
  4. ^ Altemose, Nicolas; Logsdon, Glennis A.; Bzikadze, Andrey V.; Sidhwani, Pragya; Langley, Sasha A.; Caldas, Gina V.; Hoyt, Savannah J.; Uralsky, Lev; Ryabov, Fedor D.; Shew, Colin J.; Sauria, Michael E. G.; Borchers, Matthew; Gershman, Ariel; Mikheenko, Alla; Shepelev, Valery A. (April 2022). "Complete genomic and epigenetic maps of human centromeres". Science. 376 (6588): eabl4178. doi:10.1126/science.abl4178. ISSN 0036-8075. PMC 9233505. PMID 35357911.
  5. ^ Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, et al. (October 2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  6. ^ Pertea M, Salzberg SL (2010). "Between a chicken and a grape: estimating the number of human genes". Genome Biol. 11 (5): 206. doi:10.1186/gb-2010-11-5-206. PMC 2898077. PMID 20441615.
  7. ^ "Statistics & Downloads for chromosome 6". HUGO Gene Nomenclature Committee. 2017-05-12. Archived from the original on 2017-08-18. Retrieved 2017-05-19.
  8. ^ "Chromosome 6: Chromosome summary - Homo sapiens". Ensembl Release 88. 2017-03-29. Retrieved 2017-05-19.
  9. ^ "Human chromosome 6: entries, gene names and cross-references to MIM". UniProt. 2018-02-28. Retrieved 2018-03-16.
  10. ^ "Search results - 6[CHR] AND "Homo sapiens"[Organism] AND ("genetype protein coding"[Properties] AND alive[prop]) - Gene". NCBI. 2017-05-19. Retrieved 2017-05-20.
  11. ^ "Search results - 6[CHR] AND "Homo sapiens"[Organism] AND ( ("genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) NOT "genetype protein coding"[Properties] AND alive[prop]) - Gene". NCBI. 2017-05-19. Retrieved 2017-05-20.
  12. ^ "Search results - 6[CHR] AND "Homo sapiens"[Organism] AND ("genetype pseudo"[Properties] AND alive[prop]) - Gene". NCBI. 2017-05-19. Retrieved 2017-05-20.
  13. ^ Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (August 1990). "Structure of a cannabinoid receptor and functional expression of the cloned cDNA". Nature. 346 (6284): 561–4. Bibcode:1990Natur.346..561M. doi:10.1038/346561a0. PMID 2165569. S2CID 4356509.
  14. ^ "T brachyury transcription factor". T - T brachyury transcription factor - Genetics Home Reference.
  15. ^ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3). Last update 2014-03-04. Retrieved 2017-04-26.
  16. ^ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3). Last update 2015-08-11. Retrieved 2017-04-26.
  17. ^ International Standing Committee on Human Cytogenetic Nomenclature (2013). ISCN 2013: An International System for Human Cytogenetic Nomenclature (2013). Karger Medical and Scientific Publishers. ISBN 978-3-318-02253-7.
  18. ^ Sethakulvichai, W.; Manitpornsut, S.; Wiboonrat, M.; Lilakiatsakun, W.; Assawamakin, A.; Tongsima, S. (2012). "Estimation of band level resolutions of human chromosome images". 2012 Ninth International Conference on Computer Science and Software Engineering (JCSSE). pp. 276–282. doi:10.1109/JCSSE.2012.6261965. ISBN 978-1-4673-1921-8. S2CID 16666470.
  19. ^ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
  20. ^ "p": Short arm; "q": Long arm.
  21. ^ For cytogenetic banding nomenclature, see article locus.
  22. ^ a b These values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.
  23. ^ gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere. var: Variable region; stalk: Stalk.
Notes

Further reading

Wikimedia Commons has media related to Human chromosome 6.
  • National Institutes of Health. "Chromosome 6". Genetics Home Reference. Archived from the original on 2007-08-12. Retrieved 2017-05-06.
  • "Chromosome 6". Human Genome Project Information Archive 1990–2003. Retrieved 2017-05-06.
  • "Chromosome 6 Research Project". Parent-driven research for genotype-phenotype studies on chromosome 6 disorders. Retrieved 2017-06-17

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This article is part of a series aboutJohn F. Kennedy Military service in WWII Electoral history Why England Slept Profiles in Courage A Nation of Immigrants Family 35th President of the United States Presidency timeline Transition Inauguration Tenure Executive actions New Frontier Foreign policy Doctrine A Strategy of Peace Bay of Pigs Cuban Missile Crisis Civil Rights Address Partial Nuclear Test Ban Treaty Clean Air Peace Corps We choose to go to the Moon Space programs Mercury Gemini Apol...

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This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages) The topic of this article may not meet Wikipedia's notability guideline for music. Please help to demonstrate the notability of the topic by citing reliable secondary sources that are independent of the topic and provide significant coverage of it beyond a mere trivial mention. If notability cannot be shown, the article is likely to be merge...

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Extinct species of mammal Hagerman horseTemporal range: Pliocene-Early Pleistocene Mounted skeleton of a Hagerman horse Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Chordata Class: Mammalia Order: Perissodactyla Family: Equidae Genus: Equus Subgenus: Dolichohippus Species: †E. simplicidens Binomial name †Equus simplicidensCope, 1892[1] Synonyms Plesippus shoshonensis Gidley, 1930[2] Equus simplicidens, sometimes known as the Hagerman h...

 

 

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Suzukashi Station

Railway station in Suzuka, Mie Prefecture, Japan Suzukashi Station鈴鹿市駅Suzukashi StationGeneral informationLocation1-1-1 Kambe, Suzuka-shi, Mie-ken 513-0801JapanCoordinates34°53′02″N 136°34′58″E / 34.8839°N 136.5828°E / 34.8839; 136.5828Operated by Kintetsu RailwayLine(s) Suzuka LineDistance4.1 km from Ise-WakamatsuPlatforms2 side platformsOther informationStation codeL31WebsiteOfficial websiteHistoryOpenedDecember 20, 1925Previous namesIse-Kamb...

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This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: New Jersey Junction Railroad – news · newspapers · books · scholar · JSTOR (December 2009) (Learn how and when to remove this template message) American railway from 1886 to 1952 New Jersey Junction RailroadOverviewHeadquartersWeehawken, New JerseyLocaleHudson River shore in New...

 

 

太子町 (太田市)

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The Pious Agent First editionAuthorJohn BraineCountryUnited KingdomLanguageEnglishGenreThrillerPublisherMethuenPublication date1975Media typePrint The Pious Agent is a 1975 spy thriller novel by the British writer John Braine.[1] Synopsis Xavier Flynn, a devout Catholic but ruthless agent, is on the track of a secret revolutionary movement trying to sabotage Britain. References ^ Stringer & Sutherland p.84 Bibliography Jenny Stringer & John Sutherland. The Oxford Companio...

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Haymarket Metro station

Tyne and Wear Metro station in Newcastle upon Tyne HaymarketTyne and Wear Metro stationGeneral informationLocationHaymarket, Newcastle upon TyneEnglandCoordinates54°58′39″N 1°36′50″W / 54.9775027°N 1.6139281°W / 54.9775027; -1.6139281Grid referenceNZ248648Transit authorityTyne and Wear PTEPlatforms2Tracks2ConstructionBicycle facilitiesYesAccessibleStep-free access to platformOther informationStation codeHAYFare zoneAHistoryClosed27 February 2023 (Temporary)...

 

 

Strategi Solo vs Squad di Free Fire: Cara Menang Mudah!