The album was supported by the release of "Who You Are to Me", "God Who Listens" and "Thank You Lord" as singles. "Who You Are to Me" peaked at No. 2 on the US Hot Christian Songs chart. "God Who Listens" peaked at No. 13 on the Hot Christian Songs chart. "Thank You Lord" peaked at No. 11 on the Hot Christian Songs chart.
On February 5, 2021, "God Who Listens" featuring Thomas Rhett was released as the second single from the album.[6][7] "God Who Listens" peaked at No. 13 on the Hot Christian Songs chart.[8]
On June 26, 2020, Chris Tomlin released "Thank You Lord" featuring Thomas Rhett and Florida Georgia Line, and "Who You Are to Me" featuring Lady A as the first two promotional singles from Chris Tomlin & Friends, being slated for release on July 31, 2020.[11] On July 17, 2020, Tomlin released "Be the Moon" featuring Brett Young and Cassadee Pope as the third and final promotional single from the album.[12]
Joshua Andre in his 365 Days of Inspiring Media review opined that Chris Tomlin & Friends is "one album for the ages", further adding that "this album comes pretty close" to topping Arriving or Hello Love.[13]CCM Magazine's Dan MacIntosh gave a favourable review of the album, saying "Chris Tomlin sounds like he really enjoyed making Christian music with his (mainly mainstream) friends. These friends also helped the worship music veteran make one of his best albums to date. These are good friends, indeed."[14] Timothy Yap of JubileeCast gave a lacklustre review of the album, saying, "Though Asbury's previous record had that juggernaut hit "The downfall of this project is in two areas: while Tomlin is known for crafting anthems churches can sing to, there's not one of that calibre here. Second, though this record bears his name, Tomlin plays a subsidiary role as a vocalist. One gets the feeling that this doesn't really feel like a Chris Tomlin record."[15] Rob Allwright, reviewing for One Man In The Middle, concluded: "The question has to be at the end of this, has the experiment worked? Sadly I think that overall it hasn't. The songs are easy to categorise into worship or country, there is not really any kind of blend of those genres. That's not to say that all of the songs, whether the worship numbers or the country one's are bad, but some of them are, despite the artists doing their best with them."[16] Kelly Meade, indicating in a three-point-eight star review at Today's Christian Entertainment, said "When you push play on the Chris Tomlin & Friends album, you may be surprised, as I was, by who you’re hearing on some of these songs. However, a strong message of hope and trusting in God with a solid belief is woven throughout."[17]
Reviewing for the Herald-Standard, Clint Rhodes said of the album: "With a little help from his friends, Tomlin is able to share a variety of testimonials on a compelling album about unwavering faith that encourages and transforms through a simplistic message of hope and salvation."[18] In a NewReleaseToday review, Jasmin Patterson spoke of the album, saying "Chris Tomlin & Friends is an album that will appeal to fans of Christian music, country music and lovers of all genres. It's a significant project in that it brings Christian and mainstream artists together, not only to make music, but to share their faith with one another and with their audience."[19]
In the United States, Chris Tomlin & Friends debuted at number one on the BillboardTop Christian Albums chart, having earned 12,000 equivalent album units in the first week of sales.[21] The album is Chris Tomlin's eighth chart-topping release on the Top Christian Albums chart, following Never Lose Sight (2016).[21]Chris Tomlin & Friends launched at number six on the OCC's Official Christian & Gospel Albums Chart in the United Kingdom, in the week ending August 13, 2020.[22]