He was Solicitor-General between 1824 and 1826 and Attorney General between 20 September 1826 and 27 April 1827, and again between 19 February 1828 and 29 June 1829. In May 1829, Wetherell made a violent speech in opposition to Catholic Emancipation, and was dismissed by the Duke of Wellington. He was Recorder of Bristol during the riots of 1831. From 1835 up to his death in 1846, he was Chancellor of Durham.
Family
Wetherell was twice married, first in 1826, with his cousin Jane Sarah Elizabeth Croke (1804–1831). They had a son, Charles, who died in infancy. In 1838, he married Harriet Elizabeth, daughter of Colonel Francis Warneford.