Born in Newton, Texas, he graduated from East Texas Baptist in 2006. Isom has played in Iceland, Rwanda, Angola, Portugal and the United Arab Emirates. He won the Angolan League championship in 2011, 2013 and 2016.[1]
Isom started his career with Úrvalsdeild Karla club Þór Akureyri in 2007 and quickly became one of the leagues best players.[2] He averaged 26.1 points, 7.0 rebounds and 5.5 assists during the regular season, helping Þór reach the playoffs.[3] In the playoffs, Þór lost to eventual champions Keflavík in two games.[4] He returned to Þór the following season but broke his hand in December 2008. After the injury did not heal as hoped, Isom was released in February 2009.[5]
In February 2010, Isom signed with Tindastóll for the rest of the season.[6] He appeared in eight regular season games, averaging 28.6 points, 7.1 rebounds and 8.5 assists per game. He scored a season high 48 points against Snæfell on 4 March 2010.[7] In the playoffs, he averaged 20.3 points, 6.7 rebounds and 7.3 assists per game in a 1–2 series loss against Keflavík.[8]
In 2018, Isom signed in the United Arab Emirates with Al Jazeera.
In October 2020, Isom returned to APR in Rwanda for a second stint.[9]