The Casino Mediceo di San Marco is a late-Renaissance or Mannerist style palace located on Via Cavour number 57 and via San Gallo in Florence, region of Tuscany, Italy.
In 1568–1574, the Francesco I de' Medici, Grand Duke of Tuscany and his potential half-brother Don Antonio de Medici commissioned Bernardo Buontalenti, to reconstruct the palace as a casino, a city villa, as it was sited at the Gardens of San Marco. Gherardo Silvani may also have played a role in the design. The palace was planned as a laboratory for scientific experimentation, in 1588 it became the seat of the Opificio delle Pietre Dure. On the death of Francesco I, in 1587 the palazzo was inherited by Antonio who took up residence here in 1597, commissioning numerous works for the rooms and garden which hosted sculptural groups by Giambologna.
Inside the palazzo, don Antonio created a research laboratory, known as the Fonderia, and assembled various scholars interested in chemical and alchemy. The library is now hosted by the Biblioteca Nazionale Centrale di Firenze (BNCF).[citation needed]
After the Medici, the building played various roles, barracks, customs house, ministry of finances, finally court of appeals until 2012.[2] Since 2017, the Casino Mediceo di San Marco is home of the School of Transnational Governance, part of the European University Institute.[3]
The exterior walls, windows, and portals are decorated with a whimsical array of eccentricities, a defining feature of Mannerist architecture.