The Carcarañá basin comprises 2 percent of the territory of Santa Fe and 4 percent of its population lives within it. It has a total length of 240 kilometres (150 mi) and it is navigable only by medium ships. It passes by or near the cities and towns of Inriville, Los Surgentes and Cruz Alta in Córdoba, and Arteaga, San José de la Esquina, Los Nogales, Arequito, Los Molinos, Casilda, Carcarañá, Andino and Gaboto in Santa Fe, traversing one of the richest agricultural districts in the world.
The Carcarañá's potential for the generation of hydroelectricity was taken advantage of since the 19th century and until the 1930s.