Matthews received Hugo Award nominations for his script for "Heart of Gold" and in the Graphic Story category for Serenity: Better Days.[4]
He served as an executive story editor for Supernatural. In addition, he was credited as a supervising producer and co-executive producer for The Vampire Diaries.
On April 26, 2017, MTV announced that Matthews will be the main show runner for the third season of the slasher television series Scream. The show will undergo a reboot with a new cast and setting. Matthews, Queen Latifah, Shakim Compere and Yaneley Arty will be credited as executive producers for the series under Flavor Unit Entertainment.[5] On June 24, 2019, it was announced that the rebooted Scream series would be moving to VH1 ahead of the premiere of the third season.[6] The third season, titled Scream: Resurrection, premiered on July 8, 2019.[7][8]
Currently, Matthews serves as an executive producer and writer for the CW series, Legacies.[9]
^HI-YO! Brett Matthews on the Lone Ranger's Return COMICON.com, September 6, 2006 "Archived copy". Archived from the original on 2011-01-11. Retrieved 2008-03-08.{{cite web}}: CS1 maint: archived copy as title (link)