As a freshman at Alabama, Alfano was absent from class and practices in September for unspecified reasons, though Alfano's father tweeted that his absence may have stemmed from Alfano's grandmother, who had been in ill-health at the time.[6] Alfano entered the NCAA transfer portal on September 13, 2019, and Colorado Buffaloes head coach (and former Alabama Crimson Tide defensive backs coach) Mel Tucker announced that Alfano had transferred to Colorado on November 4, 2019.[7] Alabama head coach Nick Saban addressed Alfano's time with the team by saying Alfano, "basically quit."[8] He did not play any games for the Crimson Tide.[9]
Buffaloes head coach Mel Tucker had previously recruited Alfano to Georgia, where Tucker was the defensive coordinator at the time.[10] One month after Alfano officially enrolled at Colorado, Buffaloes head coach Mel Tucker left the program to take the same position at Michigan State University, while Alfano's position coach at Colorado, Jimmy Brumbaugh, also left the program the same week to take a coaching job at the University of Tennessee.[11] On May 29, 2020, it was reported that Alfano was no longer enrolled at Colorado and no longer a member of the football team.[12] As of August 19, 2020, Alfano was reinstated to the football team.[13][14]
Without playing a game at Colorado, Alfano transferred to Independence Community College, but also never saw game action. After a year out of football, Alfano joined Lackawanna College in Pennsylvania where he played in five games, recording 14 tackles, eight tackles for loss, four sacks, one pass knockdown and one forced fumble.[15]
^Hunt, Todderick. "Breaking: N.J.'s top defender Antonio Alfano transferring from Rahway to Colonia for senior year", NJ Advance Media for NJ.com, February 23, 2018. Accessed November 13, 2019. "Top defensive end Antonio Alfano will transfer once again after moving to Rahway from Bergen Catholic last fall. This time, he'll go to Colonia (N.J.) following a change of residence from Rahway to Avenel -- a move that gains him no athletic advantage."