Born in Brăila, Romania in 1931,[4] Kefala and family moved to Greece and then New Zealand after World War II. Having studied French Literature at Victoria University and obtained a MA, she relocated to Sydney, Australia in 1960.[5] There she taught English as a second language and worked as a university and arts administrator. Her poetry and prose is written in both Greek and English, with Absence: New and Selected Poems reissued in a second edition in 1998.
Her work, written in free verse, has been described as having an almost metaphysical detachment.[6] It is characterised by an austere allusiveness unusual in Australian poetry. Aside from Greek and English it has been translated into Czech and French.[7]
In 2009, Antigone Kefala: A Writer’s Journey, an anthology of reviews, essays and analytical writing of Kefala's works edited by Professor Vrasidas Karalis and Helen Nickas was published by Owl Publishing.[8] In 2021, a collection of essays on her prose and poetry titled Antigone Kefala: New Australian Modernities, edited by Elizabeth McMahon and Brigitta Olubas, was published by UWA Publishing.
In November 2022, Kefala won the Patrick White Award.[9] A week later, she died on 3 December 2022, at the age of 91.[4]