Born in La Plata, Scopelli started his career in Argentina with Estudiantes de La Plata where he became part of the legendary side nicknamed "Los Profesores". In 1931 he scored 31 goals for the team but was beaten to the golden boot by team mate Alberto Zozaya's 33.
In 1933 Scopelli moved to Italy where he played for Roma. During this time he took the Italian citizenship (as oriundo) and played for the Italy national team. In 1936 Scopelli returned to Argentina to play for Racing Club de Avellaneda. In his later career he played for Red Star Paris in France,[3] around the start of the Second World War he moved to neutral territory to play for Belenenses and then Benfica in Portugal. In 1942 Scopelli returned to South America to play for Universidad de Chile.