He flourished in Herat (modern-day Afghanistan), under the Samanid prince Mansur I, who ruled from 961 to 976.
He was apparently the first to think of compiling a treatise on materia medica in Persian; he travelled extensively in Persia and India to obtain the necessary information.
Between 968 and 977 C.E., Muwaffaq compiled his Book of the Remedies (Kitab al-Abniya 'an Haqa'iq al-Adwiya, کتاب الابنیه عن حقائق الادویه),[2] which is the oldest prose work in New Persian.[citation needed] It is also the only work of his to survive into modern times. The book begins with an introductory general theory of pharmacology.[3] The body of the work mainly deals with over five-hundred remedies (most of which are plant-based, however seventy-five come from minerals, and forty-four from animals); they are classified into four groups according to their physiological action.[citation needed] Muwaffaq was a consummate scholar, and cited Arab, Greek, Syrian and Ayurvedic authorities.[3]