ARM390

ARM390
Names
IUPAC name
N,N-diethyl-4-[phenyl(piperidin-4-ylidene)methyl]benzamide
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C23H28N2O/c1-3-25(4-2)23(26)21-12-10-19(11-13-21)22(18-8-6-5-7-9-18)20-14-16-24-17-15-20/h5-13,24H,3-4,14-17H2,1-2H3
    Key: SMUGAZNLKPFBSB-UHFFFAOYSA-N
  • CCN(CC)C(=O)C1=CC=C(C=C1)C(=C2CCNCC2)C3=CC=CC=C3
Properties
C23H28N2O
Molar mass 348.490 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

ARM390 is an opioid-analgesic compound selective for the delta opioid receptor. In contrast to the delta-opioid selective agonist SNC-80, ARM390 was not found to produce receptor desensitization following multiple administrations. Although behavioral desensitization formed to the analgesic effect of ARM390 through a receptor internalization-independent mechanism, anxiolytic effects persisted during long-term treatment.[1] ARM390 has been dubbed a "low-internalizing agonist" of delta opioid receptors.[1]

References

  1. ^ a b Pradhan, Amynah A.; Befort, Katia; Nozaki, Chihiro; Gavériaux-Ruff, Claire; Kieffer, Brigitte L. (October 2011). "The delta opioid receptor: an evolving target for the treatment of brain disorders". Trends in Pharmacological Sciences. 32 (10): 581–590. doi:10.1016/j.tips.2011.06.008. PMC 3197801. PMID 21925742.


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