The 2021–22 season was the 117th season in the existence of Sporting de Gijón and the club's fifth consecutive season in the second division of Spanish football. In addition to the domestic league, Sporting Gijón participated in this season's edition of the Copa del Rey.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
^Ceares played its game at El Molinón, in Gijón instead of their regular stadium La Cruz as it does not meet the requirements established by the Royal Spanish Football Federation.