Starting from the round of 16, the teams were seeded according to their results in the group stage, with the group winners (Pot 1) seeded 1–8, and the group runners-up (Pot 2) seeded 9–16.[6]
In the round of 16, quarter-finals and semi-finals, each tie was played on a home-and-away two-legged basis, with the higher-seeded team hosting the second leg (Regulations Article 2.2.3.2). If tied on aggregate, the away goals rule was used. If still tied, extra time was not played, and a penalty shoot-out was used to determine the winners (Regulations Article 2.4.3).
The final was played as a single match at a venue pre-selected by the CONMEBOL, with the higher-seeded team designated as the "home" team for administrative purposes (Regulations Article 2.2.3.5). If tied after regulation, 30 minutes of extra time would be played. If still tied after extra time, a penalty shoot-out would be used to determine the winners (Regulations Article 2.4.4).
Draw
The draw for the round of 16 was held on 23 October 2020, 12:00 PYT (UTC−3).[7] For the round of 16, the 16 teams were drawn into eight ties (A–H) between a group winner (Pot 1) and a group runner-up (Pot 2), with the group winners hosting the second leg. Teams from the same association or the same group could be drawn into the same tie (Regulations Article 2.2.3.2).[3]
Bracket
The bracket starting from the round of 16 was determined as follows:
Round
Matchups
Round of 16
(Group winners hosted second leg, matchups decided by draw)
Match A
Match B
Match C
Match D
Match E
Match F
Match G
Match H
Quarter-finals
(Higher-seeded team hosted second leg)
Match S1: Winner A vs. Winner H
Match S2: Winner B vs. Winner G
Match S3: Winner C vs. Winner F
Match S4: Winner D vs. Winner E
Semi-finals
(Higher-seeded team hosted second leg)
Match F1: Winner S1 vs. Winner S4
Match F2: Winner S2 vs. Winner S3
Final
(Higher-seeded team designated as "home" team)
Winner F1 vs. Winner F2
The bracket was decided based on the round of 16 draw, which was held on 23 October 2020.
^ abThe two legs of the round of 16 match D, originally scheduled for 25 November & 2 December 2020, 21:30 local time, were re-scheduled to 2 & 9 December 2020, 21:30 local time due to the death of Diego Maradona on 25 November 2020 and his link to the club Boca Juniors.[11]