Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
^Genk qualifies for at least the play-off round of the Europa League through winning the 2021 Belgian Cup.
^On 14 April 2021 news was released that both Excel Mouscron and Oostende had not received a Belgian professional football license for the coming season, a requirement to play at the top two levels of Belgian football. For Oostende, a lack of financial transparency, together with generally poor quality and incompleteness of the submitted report, was given as the main reason by the committee for not awarding a license, while Excel Mouscron was refused a license as besides insufficient transparency, the committee also questioned several cash flows and whether the club was creditworthy in general, also due to the fact that the wages for the months of February and March had not yet been paid at that point. For Excel Mouscron, it was already the sixth year running the license was (initially) refused, however, the club has appealed the decision with the Belgian Court for Sports Arbitrage (BAS) successfully on each occasion and intended to do so again. Oostende was planning to launch an appeal as well, with the BAS to rule on the matter for both clubs before the 10th of May. Both clubs were allowed to add new documents to their case, but in case they however still did not receive a license after appeal, knew they would have been forced to relegate to the 2021–22 Belgian Division 2 and start the season with a 3-point penalty.[2] Both Excel Mouscron and Oostende were however eventually awarded a license after appeal, meaning Oostende remained at the top level, while Excel Mouscron only dropped one level.[3][4]
Stadium: Ghelamco Arena Attendance: 0 Referee: Bram van Driessche
Note: The match was originally scheduled for 28 February 2021, but was postponed after more than seven Club Brugge players tested positive for COVID-19.[8]
Source: Jupiler Pro League(in Dutch), Soccerway Rules for classification: 1) Points; 2) Points without (possible) half points added due to rounding; 3) Regular season finishing position.[9] (C) Champions
^The Dynamo Kyiv v Club Brugge match, originally scheduled at 18:55 CET(19:55 EET), was moved to 16:00 CET(17:00 EET), due to the very cold temperatures.[12]
