The 2016–17 Merkur osiguranje Handball Superleague is the 11th season of the Handball League of Serbia, Serbian's top-tier handball league. A total of twelve teams contest this season's league. RK Vojvodina are the defending champions.
Format
The competition format for the 2016–17 season consists of a home-and-away double round-robin system. The first six teams qualifies for play-offs, while the last six plays for relegation. The last two teams of this relegation round are relegated.