The 2015–16 Ukrainian Second League was the 25th season of 3rd level professional football in Ukraine. The competition commenced on 26 July 2015 with a full round of matches. From 1 November 2015 to 26 March 2016 the competition was on winter break. The competition resumed with Round 16 and completed on 1 June 2016.
FC Nikopol-NPHU – Prior to the start of the season FC NPHU-Makiyivvuhillya Nikopol formally withdrew from the PFL and then reentered under their new name.[5]
^On 19 June 2015 the Professional Football League of Ukraine confirmed the number of clubs and criteria for relegation for the next season.[6] It was decided that top two clubs would be promoted for the next season with the third playing play-off against the 14th placed team in the First League. However, two days before the end of the season, on 30 May 2016 the PFL ruled that due to sporting principles to keep 16 teams in the First League the promotion-relegation playoff match between the third placed team against the 14th placed team in the First League is cancelled and that the third placed team will be automatically promoted to the first League.[7]
^After the season the Administration of Barsa Sumy informed the PFL that they would withdraw from the professional league.[8](7 July 2016)
^Верес отримав право грати у Другій лізі [Veres obtained the right to play in the Second League] (in Ukrainian). ua-football.com. 18 June 2015. Retrieved 23 June 2014.
^Вторая лига: анонс матчей 16-го тура [Second League: Match previews Round 16] (in Ukrainian). football.sport.ua. 26 March 2016. Retrieved 9 April 2016.
^Full roster at UA-Football (inaccurate, one round behind)