The 1949 Campeonato Profesional was the second season of Colombia's top-flight football league. The tournament was started on April 25. 14 teams compete against one another and played each weekend. This tournament was famous for mark the beginning of El Dorado. Millonarios and Deportivo Cali, both with 44 points, played two final matches to decide the champion of the season. Santa Fe, the defending champion, was 3rd with 39 points.
Every team played two games against each other team, one at home and one away. Teams received two points for a win and one point for a draw. If two or more teams were tied on points, places were determined by goal difference. The team with the most points is the champion of the league.