September 9 – The Cincinnati Reds purchase Sam Crawford from Grand Rapids of the Western League. Crawford would eventually end up in the Hall of Fame as a member of the Detroit Tigers.
September 12 – The Cleveland Spiders lose both games of a doubleheader against the Philadelphia Phillies. At 19–114, they break the record for most losses by an MLB team in a single season, which had previously been 113.
September 18 - The Cleveland Spiders defeated the Washington Senators in the first game of a double header, 5–4. It would be the last win in franchise history.
October 1 – The Cleveland Spiders play their last home game, a 19–3 loss to Cincinnati. In that game, the Spiders recruited local semi-pro Eddie Kolb to pitch. It would be the 18 year old rookie's only MLB appearance.
October 15 – The Cleveland Spiders lose both games of their season-ending doubleheader against the Cincinnati Reds by scores of 16–1 and 19–3. Having lost 40 of their last 41 games, they finish the season in last place with a record of 20–134.
Buck Freeman of the Washington Senators leads all batters with 25 home runs during the regular season, more than double hit by Bobby Wallace of the St. Louis Perfectos, who finished with 12 homers. Although Freeman failed to equal the record of 27 home runs set by Ned Williamson in the 1884 season, his total is generally regarded as the greater achievement owing to the dimensions of Williamson's home ballpark of Lakeshore Park – Only two of the 27 homers batted by Williamson for the Chicago White Stockings were scored away from home. Freeman's tally was not surpassed until 1919, when Babe Ruth belted 29 home runs for the Boston Red Sox.
Following the season, the Baltimore Orioles, Cleveland Spiders, Louisville Colonels and Washington Senators were all dropped by the National League, as a cost-cutting measure, reducing the number of teams to eight for the 1900 season; while Louisville would never sport another major-league level team, the other three cities received charter franchises in the rival American League in 1901 – after being abandoned by the AL in 1971, the National League would return to the nation's capital 106 years later. The National League would remain at eight teams until 1962.
March 9 – Bill McGunnigle, 44, manager who led Brooklyn to the American Association title in 1889, and the National League pennant the following year after the team switched leagues; as collegiate catcher, was possibly the first at that position to wear a glove.
